Ganglioside GD3 disodium salt (bovine brain) An inducer of mitochondrial permeability

Ganglioside GD3 disodium salt (bovine brain) (CAS 62010-37-1)

Ganglioside GD3 disodium salt (bovine brain) | CAS 62010-37-1 is rated 5.0 out of 5 by 1.
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Synonym: Disialoganglioside GD3 2Na; GD3 2Na
Application: An inducer of mitochondrial permeability
CAS Number: 62010-37-1
Purity: ≥98%
Molecular Weight: 1516.8
Molecular Formula: C70H123N3O292Na
* Refer to Certificate of Analysis for lot specific data (including water content).
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Ganglioside GD3 disodium salt (bovine brain) induces mitochondrial permeability transition (MPT) without requiring elevated Ca2+ levels and thus triggers Fas-mediated apoptosis.


References

Apoptogenic ganglioside GD3 directly induces the mitochondrial permeability transition: B.S. Kristal & A.M. Brown; J. Biol. Chem. 274, 23169 (1999) Lipid signaling in CD95-mediated apoptosis: F. Malisan & R. Testi; FEBS Lett 452, 100 (1999), (Review) Ganglioside GD3, the mitochondrial permeability transition, and apoptosis: B.S. Kristal & A.M. Brown; Ann. NY Acad. Sci. 893, 321 (1999), (Review) Ganglioside GD3 and its mimetics induce cytochrome c release from mitochondria: Y. Inoki, et al.; BBRC 276, 1210 (2000)

Physical State :
Solid
Solubility :
Soluble in water, and chloroform/ methanol (1:1).
Storage :
Store at -20° C
Melting Point :
Decomposes
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

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Rated 5 out of 5 by from Ohkawa Ohkawa, Y. et al. (PubMed 25940087) found that Ganglioside GD3 disodium salt, an inducer of mitochondrial permeability, enhanced invasiveness of gliomas by forming a complex with PDGFR and Yes kianse. -SCBT Publication Review
Date published: 2015-06-02
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