Ganglioside GD1a disodium salt is the major ganglioside in the mammalian brain. Believed to be a differentiation marker for stem cell growth. Has shown a stimulatory effect on phagocytosis and phagosome-lysosome (P-L) fusion in a dose-dependent manner on S. aureus. Shown to modulate the Ca-dependent post-translational regulation of GAP-43. Shown to induce rapid phosphorylation of GAP-43 and stimulate ca-dependent proteolysis of GAP-43. Ganglioside GD1a disodium salt is an inhibitor of PKC.
1. Meiri, K.F. and Beverly, M. 1994. J. Neurochem. 62(1): 291-299. PMID: 8263528
2. Yamaguchi, S. et al. 1997. Glycoconj. J. 14(6): 707-714. PMID: 9337083
Hi, I ordered this product to perform a Neuraminidase 1 enzymatic assay, do you have any protocol?
Asked by: rmosca
Thank you very much for you question. We don't have an exact protocol, however, you can check the information in the three journal articles on our product page as well as the following:
Wang, Y. et al. 2015. Int. Immunopharmacol. 28(1): 136-145. PMID: 26054879
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HerediaHeredia, V. et al. (PubMed 26119566) investigated the molecular interactions between the anti-cancer agent Paclitaxel (Ptx), and two gangliosides with different sialic acid content, GM1 and GD1a using the Langmuir film balance technique. Ptx reached much higher surface pressure values in the mixed monolayers than those sustained in pure Ptx, although partial desorption of the drug from the interface into the subphase was also observed at high Ptx contents. The mean molecular area of the mixtures showed condensation, mainly in the case of GD1a, whereas Ptx induced a decrease in the compressibility of monolayers when mixed with either GM1 or GD1a. -SCBT Publication Review
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