Ganglioside GD1a disodium salt An agent with a stimulatory effect on phagocytosis and phagosome-lysosome

Ganglioside GD1a disodium salt (CAS 12707-58-3)

Ganglioside GD1a disodium salt | CAS 12707-58-3 is rated 5.0 out of 5 by 1.
  • y_2019, m_4, d_21, h_11
  • bvseo_bulk, prod_bvrr, vn_bulk_2.0.12
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_202621, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 132ms
  • REVIEWS, PRODUCT
Synonym: Disialoganglioside GD1a•2Na
Application: An agent with a stimulatory effect on phagocytosis and phagosome-lysosome
CAS Number: 12707-58-3
Purity: 98%
Molecular Weight: 1882.04
Molecular Formula: C84H146N4O392Na
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

Ganglioside GD1a disodium salt is the major ganglioside in the mammalian brain. Believed to be a differentiation marker for stem cell growth. Has shown a stimulatory effect on phagocytosis and phagosome-lysosome (P-L) fusion in a dose-dependent manner on S. aureus. Shown to modulate the Ca-dependent post-translational regulation of GAP-43. Shown to induce rapid phosphorylation of GAP-43 and stimulate ca-dependent proteolysis of GAP-43. Ganglioside GD1a disodium salt is an inhibitor of PKC.


References

1. Meiri, K.F. and Beverly, M. 1994. J. Neurochem. 62(1): 291-299. PMID: 8263528

2. Yamaguchi, S. et al. 1997. Glycoconj. J. 14(6): 707-714. PMID: 9337083

3. Yuki, N. 2010. Methods Mol. Biol. 600 : 51-65. PMID: 19882120

4. Wang, Y. et al. 2015. Int. Immunopharmacol. 28(1): 136-145. PMID: 26054879

Usage :
Supplied as a lyophilized solid.
Physical State :
Solid
Storage :
Store at -20° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
44145122
SMILES :
CCCCCCCCCCCCCCCCCC(=O)N[C@@H](COC1C(C(C(C(O1)CO)OC2C(C(C(C(O2)CO)OC3C(C(C(C(O3)CO)O)OC4C(C(C(C(O4)CO)OC5(CC([C@H](C(O5)[C@H]([C@H](CO)O)O)NC(=O)C)O)C(=O)[O-])O)O)NC(=O)C)OC6(CC([C@H](C(O6)[C@H]([C@H](CO)O)O)NC(=O)C)O)C(=O)[O-])O)O)O)[C@@H](/C=C/CCCCCCCCCCCCCCC)O.[Na+].[Na+]

Download SDS (MSDS)

Certificate of Analysis

Adobe Acrobat Reader is required to reliably view,
print and comment on PDF documents

Ganglioside GD1a disodium salt  Product Citations

See how others have used Ganglioside GD1a disodium salt. Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 23226505  Romero-Ramírez, L. et al. 2012. PloS one. 7: e49983.

Citations 1 to 1 of 1 total

Hi, I ordered this product to perform a Neuraminidase 1 enzymatic assay, do you have any protocol? thx

Asked by: rmosca
Thank you very much for you question. We don't have an exact protocol, however, you can check the information in the three journal articles on our product page as well as the following: Wang, Y. et al. 2015. Int. Immunopharmacol. 28(1): 136-145. PMID: 26054879 Please do not hesitate to contact us if you have any further question: scbt@scbt.com
Answered by: Technical Support Europe
Date published: 2017-12-29
  • y_2019, m_4, d_21, h_11CST
  • bvseo_bulk, prod_bvqa, vn_bulk_2.0.12
  • cp_1, bvpage1
  • co_hasquestionsanswers, tq_1
  • loc_en_US, sid_202621, prod, sort_[SortEntry(order=LAST_APPROVED_ANSWER_SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 93ms
  • QUESTIONS, PRODUCT
Rated 5 out of 5 by from Heredia Heredia, V. et al. (PubMed 26119566) investigated the molecular interactions between the anti-cancer agent Paclitaxel (Ptx), and two gangliosides with different sialic acid content, GM1 and GD1a using the Langmuir film balance technique. Ptx reached much higher surface pressure values in the mixed monolayers than those sustained in pure Ptx, although partial desorption of the drug from the interface into the subphase was also observed at high Ptx contents. The mean molecular area of the mixtures showed condensation, mainly in the case of GD1a, whereas Ptx induced a decrease in the compressibility of monolayers when mixed with either GM1 or GD1a. -SCBT Publication Review
Date published: 2015-07-11
  • y_2019, m_4, d_21, h_11
  • bvseo_bulk, prod_bvrr, vn_bulk_2.0.12
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_202621, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 226ms
  • REVIEWS, PRODUCT

Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2019 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.