Gambogic amide A selective agonist for Trk A

Gambogic amide (CAS 286935-60-2)

Gambogic amide is rated 5.0 out of 5 by 1.
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Application: A selective agonist for Trk A
CAS Number: 286935-60-2
Purity: ≥98%
Molecular Weight: 627.77
Molecular Formula: C38H45NO7
* Refer to Certificate of Analysis for lot specific data (including water content).

Gambogic amide is a selective agonist for Trk A which mimics the actions of NGF. This compound possesses robust neurotrophic actvity, while it prevents neuronal cell death.1


References

1. Jang, Sung-Wuk., et al., 2007. Gambogic amide, a selective agonist for TrkA receptor that possesses robust neurotrophic activity, prevents neuronal cell death. Proceedings of the National Academy of Sciences of the United States of America. 104(41): 16329-34. PMID: 17911251

Physical State :
Solid
Solubility :
Soluble in DMSO (20 mg/ml), and ethanol (20 mg/ml).
Storage :
Store at -20° C
Melting Point :
74-76° C
Boiling Point :
~823.9° C at 760 mmHg (Predicted)
Density :
~1.3 g/cm3 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
56951189
SMILES :
CC(=CCC[C@@]1(C=CC2=C(O1)C(=C3C(=C2O)C(=O)C4=C[C@@H]5C[C@@H]6[C@@]4(O3)[C@](C5=O)(OC6(C)C)C/C=C(/C)C(=O)N)CC=C(C)C)C)C

Download SDS (MSDS)

Certificate of Analysis

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Rated 5 out of 5 by from Shen Shen, J. et al. (PubMed 25712642) reported that Gambogic amide selectively upregulates TrkA expression and triggers its activation. -SCBT Publication Review
Date published: 2015-06-10
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