Fusidic acid sodium salt An antibiotic, nitric oxide suppressor, and protein synthesis inhibitor

Fusidic acid sodium salt (CAS 751-94-0)

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Synonym: Sodium fusidate
Application: An antibiotic, nitric oxide suppressor, and protein synthesis inhibitor
CAS Number: 751-94-0
Purity: ≥98%
Molecular Weight: 538.7
Molecular Formula: C31H47O6•Na
* Refer to Certificate of Analysis for lot specific data (including water content).
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Fusidic acid sodium salt, a triterpenoid compound, displays a capacity to inhibit lysis of isolated islet cells by activated microphages via suppression of nitiric oxide toxicity. Other studies have shown Furisdic acid to have immunomodulatory effects related to decrease in cytokine production in animal models of insuln dependent diabetes and septic shock. In vitro studies suggest that Furisdic acid acts against many pathogens including Staphylococcus aureus, gram-positive anaerobic bacteria, Neisseria spp., Bordetella pertussis, and Moraxella catarrhalis. In addition, this compound has been noted to inhibit the function of neutrophils and T-lymphocytes. The mechanism behind these inhibitions is known to be due to interference of protein synthesis via suppression of EF-G (elongation factor G) at the level of the ribosome. This product is offered in the sodium salt form which is found to be more water-soluble.


References

1. Burkart, V., et al. 1994. Biochem. Pharmacol. 48: 1379-1385. PMID: 7945436
2. Collignon, P., et al. 1999. Int. J. Antimicrob. Agents. 12: S45-S58. PMID: 10528786
3. Christiansen, K. 1999. Int. J. Antimicrob. Agents. 12: S73-S78. PMID: 10528789
4. Howden, B.P. and Grayson, M.L. 2006. Clin. Infect. Dis. 42: 394-400. PMID: 16392088

Physical State :
Solid
Solubility :
Soluble in water (50 mg/ml), chloroform(1:350), and alcohol(1:1).
Storage :
Store at 4° C
Boiling Point :
635.6° C at 760 mmHg (Predicted)
Refractive Index :
n20D ~1.56 (Predicted)
IC50 :
Plasmodium falciparum: IC50 = 12.59 µM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
LV5775000
PubChem CID :
23672955
Merck Index :
14: 4317
MDL Number :
MFCD09054714
EC Number :
212-030-3
SMILES :
[Na+].C[C@@H]1[C@H](O)CC[C@@]2(C)[C@H]1CC[C@@]1(C)[C@H]2[C@H](O)C[C@@H]2[C@]1(C)C[C@H](OC(C)=O)\\C2=C(\\CC\\C=C(/C)C)C([O-])=O

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Certificate of Analysis

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Fusidic acid sodium salt  Product Citations

See how others have used Fusidic acid sodium salt. Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 24004247  2013. J Phys Chem B. 117: 10798-806.

Citations 1 to 1 of 1 total
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Rated 5 out of 5 by from Milenkovi M; et al Milenkovi M; et al. (PubMed ID: 16216521) demonstrated that Fusidic acid sodium salt decreased experimental autoimmune myocarditis (EAM) in Rats. -SCBT Publication Review
Date published: 2015-05-23
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