Fusidic acid sodium salt, a triterpenoid compound, displays a capacity to inhibit lysis of isolated islet cells by activated microphages via suppression of nitiric oxide toxicity. Other studies have shown Furisdic acid to have immunomodulatory effects related to decrease in cytokine production in animal models of insuln dependent diabetes and septic shock. In vitro studies suggest that Furisdic acid acts against many pathogens including Staphylococcus aureus, gram-positive anaerobic bacteria, Neisseria spp., Bordetella pertussis, and Moraxella catarrhalis. In addition, this compound has been noted to inhibit the function of neutrophils and T-lymphocytes. The mechanism behind these inhibitions is known to be due to interference of protein synthesis via suppression of EF-G (elongation factor G) at the level of the ribosome. This product is offered in the sodium salt form which is found to be more water-soluble.
1. Burkart, V., et al. 1994. Biochem. Pharmacol. 48: 1379-1385. PMID: 7945436
2. Collignon, P., et al. 1999. Int. J. Antimicrob. Agents. 12: S45-S58. PMID: 10528786
3. Christiansen, K. 1999. Int. J. Antimicrob. Agents. 12: S73-S78. PMID: 10528789
4. Howden, B.P. and Grayson, M.L. 2006. Clin. Infect. Dis. 42: 394-400. PMID: 16392088
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