FURA 2/AM A highly selective Ca2+ fluorescent chelator

FURA 2/AM (CAS 108964-32-5)

FURA 2/AM | CAS 108964-32-5 is rated 4.5 out of 5 by 2.
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Synonym: FURA-2AM
Application: A highly selective Ca2+ fluorescent chelator
CAS Number: 108964-32-5
Molecular Weight: 1001.85
Molecular Formula: C44H47N3O24
* Refer to Certificate of Analysis for lot specific data (including water content).
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FURA 2/AM is the cell-permeable ester form of FURA 2 (sc-221644 & sc-202163), which is a fluorescent chelator (Kd = 224 nM) selective for Ca2+ over other ions and offers 30 times greater fluorescence intensity than QUIN 2 (sc-202303). FURA 2/AM is rapidly metabolized in the cell by cytoplasmic esterases; yielding the active dye FURA 2. FURA 2/AM can be used as a probe to determine calcium concentrations in many cellular systems, including: cardiac myocytes, vascular smooth muscle cells, and medullary collecting tubules. Spectral properties in the presence of low calcium concentrations (excitation max = 362 nm, emission max = 512 nm) differ from those during high calcium conditions (excitation max = 335 nm, emission max = 505 nm).


References

1. Maruyama, I., et al. 1987. FEBS Lett. 220: 89-92. PMID: 3609323
2. Davis, M.J., et al. 1992. Am. J. Physiol. 263: H1292-H1299. PMID: 1329564
3. Field, M.L., et al. 1994. Cell Calcium. 16: 87-100. PMID: 7982268
4. Tran, N.N., et al. 1995. Cell Calcium. 18: 420-428. PMID: 8581970
5. Nakamura, I., et al. 1996. Tohoku J. Exp. Med. 179: 291-294. PMID: 8944431
6. Fu, L.W., et al. 1997. Yao Xue Xue Bao. 32: 401-405. PMID: 11596320

Physical State :
Solid
Solubility :
Soluble in DMSO (10 mg/ml), DMF, CH3CN, CH2Cl2, EtOAc, acetone (10 mg/ml), and chloroform.
Storage :
Store at -20° C
Boiling Point :
975.91° C at 760 mmHg (Predicted)
Density :
1.40 g/cm3
Refractive Index :
n20D 1.57 (Predicted)
Fluoresence :
λex 335-362 nm, λem 505-512 nm; λex 369 nm, λem 471 nm in ethyl acetate(prior to hydrolysis of AM esters in cell)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
3086531
MDL Number :
MFCD00036976
Beilstein Registry :
8183748
SMILES :
CC1=CC(=C(C=C1)N(CC(=O)OCOC(=O)C)CC(=O)OCOC(=O)C)OCCOC2=C(C=CC3=C2C=C(O3)C4=NC=C(O4)C(=O)OCOC(=O)C)N(CC(=O)OCOC(=O)C)CC(=O)OCOC(=O)C

Download SDS (MSDS)

Certificate of Analysis

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FURA 2/AM  Product Citations

See how others have used FURA 2/AM. Click on the entry to view the PubMed entry .

Citations 1 to 4 of 4 total

PMID: # 26803937  Aguettaz, E. et al. 2016. Cell Calcium. 59: 145-55.

PMID: # 27617280  Aguettaz, E. et al. 2016. Data Brief. 8: 1443-7.

PMID: # 23426965  Das, J. et al. 2014. J Acupunct Meridian Stud. 7: 140-50.

PMID: # 24929458  Das, J. et al. 2014. J Acupunct Meridian Stud. 7: 140-50.

Citations 1 to 4 of 4 total

What is the appearance of the compound?

Asked by: two2igm05
Thank you for your question. FURA 2/AM, sc-203052, is a yellow solid.
Answered by: Chemical Support 4
Date published: 2017-03-08
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Rated 4 out of 5 by from great product I used to purchase from other vendor. I shifted to this product because of cost and found it is great. Highly recommended
Date published: 2017-05-18
Rated 5 out of 5 by from Hung TY; et Hung TY; et. Al, (PubMed ID: 26387654) utilized FURA 2/AM (a fluorescent dye commonly used to measure Ca2+ concentration) to interpret the effect of Safrole on free cystolic Ca2+. -SCBT Publication Review
Date published: 2015-06-27
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