Fumitremorgin C A strong and specific BRCP inhibitor

Fumitremorgin C (CAS 118974-02-0)

Fumitremorgin C | CAS 118974-02-0 is rated 5.0 out of 5 by 1.
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Application: A strong and specific BRCP inhibitor
CAS Number: 118974-02-0
Purity: >95%
Molecular Weight: 379.5
Molecular Formula: C22H25N3O3
* Refer to Certificate of Analysis for lot specific data (including water content).
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Fumitremorgin C (FTC) is a diketopiperazine, fungal toxin, that acts as a strong and specific ABCG2/BRCP (ATP-binding cassette G2/breast cancer resistance protein) inhibitor. Studies indicate that FTC inhibits cell cycle progression in the M phase of tsFT210 mouse cells. Isolated from Aspergillus fumigatus, FTC has been proved to revert resistance to topotecan, mitoxanthrone, doxorubicin, in S1-M1–3.2 cells that over express BRCP/ABCG2 mRNA. Reports suggest that FTC inhibits BRCP/ABCG2-mediated transport, which results in the re-sensitization of drug-resistant cells. FTCs neurotoxicity has lead researchers to investigate analogues of FTC, such as Ko143.


References

1. Cui, C.B., et al. 1996. J. Antibiot. 49: 527-533. PMID: 8698634
2. Rabindran, S.K., et al. 2000. Cancer Res. 60: 47-50. PMID: 10646850
3. Allen, J.D., et al. 2002. Mol. Cancer Ther. 1: 417-425. PMID: 12477054

Appearance :
Lyophilized
Physical State :
Solid
Derived From :
Aspergillus fumigatus
Solubility :
Soluble in acetonitrile (5 mg/ml), methanol (5 mg/ml), DMSO, chloroform, ethanol, and DMF.
Storage :
Store at 4° C
Melting Point :
257.12° C (Predicted)
Boiling Point :
642.93° C at 760 mmHg (Predicted)
Density :
1.34 g/cm3 (Predicted)
Refractive Index :
n20D 1.68 (Predicted)
IC50 :
ATP-binding cassette sub-family G member 2: IC50 = 800 nM (human); K562 (Erythroleukemia cells): IC50 = 41 µM (human)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
403923
MDL Number :
MFCD08702652
SMILES :
COC1=CC2=C(C=C1)C1=C(N2)[C@H](\\C=C(/C)C)N2[C@@H](C1)C(=O)N1CCC[C@H]1C2=O

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Certificate of Analysis

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Fumitremorgin C  Product Citations

See how others have used Fumitremorgin C. Click on the entry to view the PubMed entry .

Citations 1 to 5 of 5 total

PMID: # 18820285  Hu, C. et al. 2008. Carcinogenesis. 29: 2289-2297.

PMID: # 12477054  Allen, JD. et al. 2002. Mol. Cancer Ther. 1: 417-425.

PMID: # 11437380  Ozvegy, C. et al. 2001. Biochem. Biophys. Res. Commun. 285: 111-117.

PMID: # 10646850  Rabindran, SK. et al. 2000. Cancer Res. 60: 47-50.

PMID: # 328548  Cole, RJ. et al. 1977 Jul-Aug. J. Agric. Food Chem. 25: 826-830.

Citations 1 to 5 of 5 total
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Rated 5 out of 5 by from Zhou Zhou, Q. et al. (PubMed 26305906) demonstrated that Fumitremorgin C, a strong and specific BRCP inhibitor, reduced breast cancer stem cell survival to a similar degree as curcumin. -SCBT Publication Review
Date published: 2015-04-05
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