Fumitremorgin C (FTC) is a diketopiperazine, fungal toxin, that acts as a strong and specific ABCG2/BRCP (ATP-binding cassette G2/breast cancer resistance protein) inhibitor. Studies indicate that FTC inhibits cell cycle progression in the M phase of tsFT210 mouse cells. Isolated from Aspergillus fumigatus, FTC has been proved to revert resistance to topotecan, mitoxanthrone, doxorubicin, in S1-M1–3.2 cells that over express BRCP/ABCG2 mRNA. Reports suggest that FTC inhibits BRCP/ABCG2-mediated transport, which results in the re-sensitization of drug-resistant cells. FTCs neurotoxicity has lead researchers to investigate analogues of FTC, such as Ko143.
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See how others have used Fumitremorgin C. Click on the entry to view the PubMed entry .
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