Fosfomycin Disodium Salt is an antibiotic produced by Streptomyces fradiae. It is a phosphoenolpyruvate analog that irreversibly inhibits UDP-GlcNAc enolpyruvyl tranferase (MurA), an enzyme involved in bacterial cell wall biosynthesis. This, in turn, inhibits the production of N-acetylmuramic acid, an essential element of the peptidoglycan cell wall. Fosfomycin disodium salt concentrates in the kidney and bladder, thereby reducing nephrotoxicity and ototoxicity of platinum-containing antitumor agents.
Goto, M., et al.: Antimicrob. Agents Chemother., 20, 393 (1981),
Soluble in Water
Store at 4° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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Marqu sMarqu s, C. et al. (PubMed 26297246) characterized the effects of Fosfomycin on in vitro biofilm formed by a representative strain of meticillin-susceptible Staphylococcus aureus (MSSA) isolated from a bone infection. The presence of Fosfomycin during the initial steps of biofilm formation resulted in significant decreases in the number of sessile viable bacteria at the highest concentrations tested. -SCBT Publication Review
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