Forskolin An adenylate cyclase activator and MAP kinase inhibitor

Forskolin (CAS 66575-29-9)

Forskolin | CAS 66575-29-9 is rated 5.0 out of 5 by 2.
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Synonym: Colforsin; Coleonol;7β-Acetoxy-8,13-epoxy-1α,6β,9α-trihydroxylabd-14-en-11-one
Application: An adenylate cyclase activator and MAP kinase inhibitor
CAS Number: 66575-29-9
Purity: ≥98%
Molecular Weight: 410.50
Molecular Formula: C22H34O7
* Refer to Certificate of Analysis for lot specific data (including water content).
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Forskolin is a diterpenoid isolated from Coleus forskohlii, interacts directly with the catalytic subunit of A cyclase (adenylate cyclase), activating the enzyme and raising intracellular levels of cAMP. Forskolin is cell permeable and active in vivo producing positive inotropic, platelet anti-aggregatory and anti-hypertensive effects in vitro. Has also been shown to exhibit smooth muscle relaxant activity, decrease in intraocular pressure and the promotion of hormonal release from the pituitary glands in vitro. Inhibits MAP kinase, induces phosphorylation of CREB, connexin 43, Bad, ATF-1 and PKB. Forskolin is an inhibitor of AChR.


References

1. Laurenza, A., et al., 1989. Forskolin: a specific stimulator of adenylyl cyclase or a diterpene with multiple sites of action? Trends in pharmacological sciences. 10(11): 442-7. PMID: 2692256
2. Seamon, K B., et al., 1986. Forskolin: its biological and chemical properties. Advances in cyclic nucleotide and protein phosphorylation research. 20(): 1-150. PMID: 3028083
3. de Souza, N J., et al., . Forskolin: a labdane diterpenoid with antihypertensive, positive inotropic, platelet aggregation inhibitory, and adenylate cyclase activating properties. Medicinal research reviews. 3(2): 201-19. PMID: 6345959

Usage :
Forskolin is soluble in ethanol and DMSO.
Appearance :
Crystalline
Physical State :
Solid
Solubility :
Soluble in DMSO (5 mg/ml), ethanol, methanol, and Chloroform.
Storage :
Store at -20° C
Melting Point :
223-227° C
Boiling Point :
~519.9° C at 760 mmHg (Predicted)
Density :
~1.2 g/cm3 (Predicted)
Refractive Index :
n20D 1.55
Optical Activity :
α20/D -20.13°, c = 1.5 in chloroform
IC50 :
MAP kinase: IC50 = 25 µM (rat renal mesangial cells); adenylyl cyclase: IC50 = 41 nM
Ki Data :
adenylate cyclase: Ki= 29.4 nM
pK Values :
pKa: 11.00
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
QL6150000
PubChem CID :
47936
Merck Index :
14: 2476
MDL Number :
MFCD00082317
EC Number :
266-410-9
Beilstein Registry :
1692716
SMILES :
CC(=O)O[C@H]1[C@H]([C@@H]2[C@]([C@H](CCC2(C)C)O)([C@@]3([C@@]1(O[C@@](CC3=O)(C)C=C)C)O)C)O

Download SDS (MSDS)

Certificate of Analysis

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Forskolin  Product Citations

See how others have used Forskolin. Click on the entry to view the PubMed entry .

Citations 1 to 10 of 30 total

PMID: # 29056548  Shafa, M. et al. 2017. Cytotherapy.

PMID: # 28099152  Jelinic, P. et al. 2017. Oncotarget. 8: 13792-13804.

PMID: # 28676429  Cavalcante, IP. et al. 2017. Mol. Cell. Endocrinol.

PMID: # 26481310  Liu, Z. et al. 2016. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 30: 635-52.

PMID: # 25700266  Peng, JY. et al. 2015. Domest. Anim. Endocrinol. 52: 1-10.

PMID: # 26054746  Peng, J. et al. 2015. Mol. Cell. Endocrinol. 412: 104-15.

PMID: # 25391795  Kedziora, KM. et al. 2015. Methods Mol. Biol. 1251: 67-82.

PMID: # 26264578  Zhang, Y. et al. 2015. Human molecular genetics. 24: 6029-40.

PMID: # 24141182  Sunkara, LT. et al. 2014. Mol. Immunol. 57: 171-80.

PMID: # 24935537  Limjeerajarus, CN. et al. 2014. Journal of endodontics. 40: 925-30.

Citations 1 to 10 of 30 total

We are planning to switch this compound from SIGMA to Santa Cruz. Can you provide us the trial so that we can test the repeatability of data?

Asked by: Shogo
Thank you for your question. We do not provide sample sizes for any of our chemical reagents. We do offer a satisfaction guarantee. Any product that does not meet the performance standards indicated in our product literature will be replaced at no charge. Our policy is valid for one year from the date of purchase.
Answered by: Technical Support
Date published: 2018-11-19

Can Forskolin be filtered through a 0.2 micron filter?

Asked by: ChemSynth123
Thank you for your question. Forskolin (CAS 66575-29-9): sc-3562, is probably only about a nanometer across. If it is truly in solution, and not a suspension of particles (especially >0.2 µm, of course), it should pass through the 0.2 micron filter just fine.
Answered by: Chemical Support 7
Date published: 2017-03-01
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Rated 5 out of 5 by from We use this routinely in our lab and it works We use this routinely in our lab and it works great.
Date published: 2015-08-31
Rated 5 out of 5 by from Vitolo Vitolo, et. al. (PubMed ID 12244210) found that forskolin triggers PKA Kinase activity and promotes the recovery of LTP formation. -SCBT Publication Review
Date published: 2015-06-13
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