Foroxymithine is a potent chelator of the ferrous ion and specific inhibitor of ACE (angiotensin I converting enzyme) at an IC50 of 7μg/ml. Although Foroxymithine potently inhibits ACE activity if a high enough concentration of plasma renin activity is detected by ACE the inhibitory effects will be nullified. When the compound was administered with Erbstatin Analog (sc-200511), both displayed growth inhbitiory activity against L-1210 leukemia cells in vitro.
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