(+)-Fluprostenol A metabolically stable PGF2αR agonist

(+)-Fluprostenol (CAS 54276-17-4)

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Synonym: (5Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(1E,3R)-3-hydroxy-4-[3-(trifluoromethyl)phenoxy]-1-butenyl]cyclopentyl]-5-heptenoic Acid; [1R-[1α(Z),2β(1E,3R*),3α,5α]]-7-[3,5-Dihydroxy-2-[3-hydroxy-4-[3-(trifluoromethyl)phenoxy]-1-butenyl]cyclopentyl]-5-heptenoic Acid
Application: A metabolically stable PGF2αR agonist
CAS Number: 54276-17-4
Purity: >90%
Molecular Weight: 458.47
Molecular Formula: C23H29F3O6
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(+)-Fluprostenol is the optically active enantiomer of fluprostenol (sc-201336). It is a metabolically stable analog of PGF2α and a potent FP prostanoid receptor (PGF2αR) agonist. The expected potency of (+)-fluprostenol is twice that of (+/-)-fluprostenol for PGF2α binding to human and rat FP receptors. (+)-Fluprostenol is an effective inhibitor of rat adipose precursor differentiation in primary cultures.


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2. Lake, S., et al., 1994. Cloning of the rat and human prostaglandin F2 alpha receptors and the expression of the rat prostaglandin F2 alpha receptor. FEBS letters. 355(3): 317-25. PMID: 7988697
3. Abramovitz, M., et al., 1994. Cloning and expression of a cDNA for the human prostanoid FP receptor. The Journal of biological chemistry. 269(4): 2632-6. PMID: 8300593
4. Serrero, G., et al., 1997. Prostaglandin F2alpha receptor (FP receptor) agonists are potent adipose differentiation inhibitors for primary culture of adipocyte precursors in defined medium. Biochemical and biophysical research communications. 233(1): 200-2. PMID: 9144422

Formulation :
1% solution in ethanol
Physical State :
Storage :
Store at -20° C
Boiling Point :
78° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
MDL Number :

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