Fluoxetine hydrochloride An ST (SERT) inhibitor

Fluoxetine hydrochloride (CAS 56296-78-7)

Fluoxetine hydrochloride | CAS 56296-78-7 is rated 5.0 out of 5 by 1.
  • y_2019, m_5, d_18, h_17
  • bvseo_bulk, prod_bvrr, vn_bulk_2.0.12
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_201125, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 71ms
  • REVIEWS, PRODUCT
Synonym: (±)-N-Methyl-γ-[4-(trifluoromethyl)phenoxy]benzenepropanamine hydrochloride
Application: An ST (SERT) inhibitor
CAS Number: 56296-78-7
Purity: ≥98%
Molecular Weight: 345.79
Molecular Formula: C17H18F3NO•HCl
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

Fluoxetine is an ST (5-hydroxytryptamine/serotonin/5-HT reuptake) inhibitor. This is a racemic mixture and both R and S enantiomers which are reported to inhibit 5-HT uptake in synaptosomal preparations of rat cerebral cortex. Additionally, Fluoxetine is also noted to increase extracellular levels of 5-HT in several areas of the rat brain as a result of reuptake inhibition. This increase in availability of 5-HT is reported to lead to a decrease in synthesis and turnover of 5-HT.


References

1. Wong, D.T., et al. 1995. Life Sci. 57: 411-441. PMID: 7623609
2. Beck, S.G., et al. 1997. J. Pharmacol. Exp. Ther. 281: 115-122. PMID: 9103487
3. Owens, M.J., et al. 1997. J. Pharmacol. Exp. Ther. 283: 1305-1322. PMID: 9400006

Usage :
Store, as supplied, at room temperature for up to 1 year. Store solutions at -20°C for up to 3 months.
Physical State :
Solid
Solubility :
Soluble in water (4 mg/mL), DMSO (>5 mg/mL), acetone, acetonitrile, chloroform, and methanol.
Storage :
Store at room temperature
Melting Point :
158-159° C
IC50 :
5HT2c receptor: IC50 = ~20 µM
Ki Data :
5-HT transporter: Ki= 0.9 nmol/l (human); Serotonin transporter: Ki= 2 nM (Rattus norvegicus)
pK Values :
pKa: 8.7, pKb: 10.05 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
UI4050000
PubChem CID :
62857
Merck Index :
14: 4185
MDL Number :
MFCD00214288
EC Number :
260-101-2
SMILES :
CNCCC(C1=CC=CC=C1)OC2=CC=C(C=C2)C(F)(F)F.Cl

Download SDS (MSDS)

Certificate of Analysis

Adobe Acrobat Reader is required to reliably view,
print and comment on PDF documents

Fluoxetine hydrochloride  Product Citations

See how others have used Fluoxetine hydrochloride. Click on the entry to view the PubMed entry .

Citations 1 to 7 of 7 total

PMID: # 26645631  Alboni, S. et al. 2017. Mol. Psychiatry. 22: 552-561.

PMID: # 27474084  Alboni, S. et al. 2016. Brain Behav. Immun. 58: 261-271.

PMID: # 25956871  McAllister, BB. et al. 2015. Behavioural brain research. 290: 102-16.

PMID: # 24570000  Tanaka, T.|Doe, JM.|Horstmann, SA.|Ahmad, S.|Ahmad, A.|Min, SJ.|Reynolds, PR.|Suram, S.|Gaydos, J.|Burnham, EL.|Vandivier, RW.| et al. 2014. J. Biol. Chem. 289: 10466-75.

PMID: # 15379001  Henry, TB. et al. 2004. Environ. Toxicol. Chem. 23: 2229-2233.

PMID: # 12401330  Hall, FS. et al. 2002. Neuroscience. 115: 153-161.

PMID: # 11733460  Lass-Flörl, C. et al. 2001. J. Antimicrob. Chemother. 48: 775-779.

Citations 1 to 7 of 7 total

 I want to dissolve it, aliquot it and store it long term at -20C. Should I use water or DMSO for this?

Asked by: SCM4
Fluoxetine hydrochloride may be stored as supplied at room temperature for up to 1 year. An aqueous solution (4mg/ml) may be stored at -20°C for up to 3 months.
Answered by: Tech Service 11
Date published: 2017-03-02
  • y_2019, m_5, d_18, h_17CST
  • bvseo_bulk, prod_bvqa, vn_bulk_2.0.12
  • cp_1, bvpage1
  • co_hasquestionsanswers, tq_1
  • loc_en_US, sid_201125, prod, sort_[SortEntry(order=LAST_APPROVED_ANSWER_SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 142ms
  • QUESTIONS, PRODUCT
Rated 5 out of 5 by from Henry et al Henry et al. (PubMed ID 15379001) found, selective serotonin reuptake inhibitor, Fluoxetine hydrochloride, to negatively impact C. dubia survival and reproduction when in high concentrations. -SCBT Publication Review
Date published: 2015-04-03
  • y_2019, m_5, d_18, h_17
  • bvseo_bulk, prod_bvrr, vn_bulk_2.0.12
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_201125, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 237ms
  • REVIEWS, PRODUCT

Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2019 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.