Fluconazole A triazole broad-spectrum antifungal agent particularly for candida species

Fluconazole (CAS 86386-73-4)

Fluconazole | CAS 86386-73-4 is rated 5.0 out of 5 by 1.
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Synonym: a-(2,4-Difluorophenyl)-a-(1H-1,2,4-triazol-1- ylmethyl)-1H-1,2,4-triazole-1-ethanol
Application: A triazole broad-spectrum antifungal agent particularly for candida species
CAS Number: 86386-73-4
Purity: ≥98%
Molecular Weight: 306.27
Molecular Formula: C13H12F2N6O
* Refer to Certificate of Analysis for lot specific data (including water content).
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Fluconazole is a triazole broad-spectrum antifungal agent which is effective against Candida spp., cryptococcus neoformans and dermatophytes. Fluconazole is an inhibitor of CYP2C19, CYP2C9 and CYP3A4.


References

1. Vincent-Ballereau, F.N., et al. 1991. Pharm. Weekbl. Sci. 13: 45-57. PMID: 1870943
2. Martin, M.V. 1999. J. Antimicrob Chemother. 44: 429-437. PMID: 10588302

Appearance :
Crystalline powder
Physical State :
Solid
Solubility :
Soluble in water (<1 mg/ml at 25° C), ethanol (61 mg/ml at 25° C), and DMSO (61 mg/ml at 25° C).
Storage :
Store at room temperature
Melting Point :
138-142° C
Boiling Point :
~579.8° C at 760 mmHg (Predicted)
Density :
~1.5 g/cm3 (Predicted)
Refractive Index :
n20D 1.66 (Predicted)
IC50 :
CYP51A1: IC50 = 0.13 µM (human); Candida albicans: IC50 = 0.30 µM; Candida parapsilosis: IC50 = 0.69 µM; Cryptococcus neoformans: IC50 = 1.47 µM; Trichophyton mentagrophytes: IC50 = 1.96 µM
Ki Data :
Mdr-1: Ki>0.4 mM (human); P-glycoprotein 1: Ki>1 mM (mouse); P-glycoprotein 3: Ki>1 mM (mouse)
pK Values :
pKa: 11.01 (Predicted), pKb: 2.94 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
XZ4810000
PubChem CID :
3365
Merck Index :
14: 4122
MDL Number :
MFCD00274549
SMILES :
C1=CC(=C(C=C1F)F)C(CN2C=NC=N2)(CN3C=NC=N3)O

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Certificate of Analysis

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Fluconazole  Product Citations

See how others have used Fluconazole. Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 22851130  Gillies, AT. et al. 2012. Molecular bioSystems. 8: 2901-8.

Citations 1 to 1 of 1 total

What is the potency of the drug? In micrograms/mg

Asked by: Karthik
Thank you for your question. Unfortunately we do not have the potency of this compound. The following literature sources may be of some assistance: 1. Herbrecht, R.,Nivoix, Y.,Fohrer, C., et al. Management of systemic fungal infections: Alternatives to itraconazole. J. Antimicrob. Chemother. 56(Suppl 1),i39-i48 (2005). PMID: 16120633 2. Saag, M.S., and Dismukes, W.E. Azole antifungal agents: Emphasis on new triazoles. Antimicrobial Agents and Chemotherapy 32(1), 1-8 (1988).PMID: 2831809 Please contact Technical Service by phone, (800)-457-3801 option 2, email &lt;scbt@scbt.com&gt;, or by live chat directly on our website, www.scbt.com if you have any further questions.
Answered by: Technical Service
Date published: 2017-07-18
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Rated 5 out of 5 by from Shubitz LF; et al Shubitz LF; et al. (PubMed ID: 26369964) used Fluconazole, an antifungal as a control to evaluate VT-1161 as a form of treatment for Coccidioidomycosis in mice. -SCBT Publication Review
Date published: 2015-02-23
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