Flt-3 InhibitorA cell-permeable thienylcarboxamide compound that acts as an ATP-competitive

Flt-3 Inhibitor (CAS 301305-73-7)

Flt-3 Inhibitor | CAS 301305-73-7 is rated 5.0 out of 5 by 1.
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Synonym: 2-(3,4-Dimethoxy-benzoylamino)-4,5,6,7-tetrahydro-benzo[b]thiophene-3-carboxylic acid amide
Application: A cell-permeable thienylcarboxamide compound that acts as an ATP-competitive
CAS Number: 301305-73-7
Purity: ≥98%
Molecular Weight: 360.43
Molecular Formula: C18H20N2O4S
* Refer to Certificate of Analysis for lot specific data (including water content).
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Flt-3 Inhibitor is a cell-permeable thienylcarboxamide compound that acts as a potent, ATP-competitive, and highly selective Flt-3/Flk-2 (Flt-3) inhibitor (IC50 = 42 nM) with little effect against a panel of 22 other kinases (IC50 ≥3 μM).


References

Patch, R.J., et al. 2006. Bioorg. Med. Chem. Lett. 16, 3282.

Physical State :
Solid
Solubility :
Soluble in water (<2 mg/ml), DMSO (15 mg/ml at 25° C), and ethanol (<1 mg/ml at 25° C).
Storage :
Store at -20° C
Melting Point :
257.34° C (Predicted)
Boiling Point :
~454.4° C at 760 mmHg (Predicted)
Density :
~1.3 g/cm3 (Predicted)
Refractive Index :
n20D 1.64 (Predicted)
IC50 :
Flt-3/Flk-2: IC50 = 42 nM; MV4-11: IC50 = 340 nM (human)
pK Values :
pKa: 12.43 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
1048845
MDL Number :
MFCD00617269
SMILES :
COC1=C(C=C(C=C1)C(=O)NC2=C(C3=C(S2)CCCC3)C(=O)N)OC

Download SDS (MSDS)

Certificate of Analysis

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Flt-3 Inhibitor  Product Citations

See how others have used Flt-3 Inhibitor. Click on the entry to view the PubMed entry .

Citations 1 to 2 of 2 total

PMID: # 15141010  Warshamana-Greene, GS. et al. 2004. Mol. Cancer Ther. 3: 527-535.

PMID: # 15150124  George, P. et al. 2004. Cancer Res. 64(10): 3645-3652.

Citations 1 to 2 of 2 total
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Rated 5 out of 5 by from Patch Patch, RJ. et al. (PubMed 16580199) tested Flt-3 Inhibitor (2-(3,4-Dimethoxy-benzoylamino)-4,5,6,7-tetrahydro-benzo[b]thiophene-3-carboxylic acid amide) against several other derivatives. Found that the inhibitor was both potent and highly selective for Flt-3 at low concentrations (IC50 0.043 M). -SCBT Publication Review
Date published: 2015-06-19
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