Fidaxomicin A macrocyclic antibiotic

Fidaxomicin (CAS 873857-62-6)

Fidaxomicin | CAS 873857-62-6 is rated 5.0 out of 5 by 1.
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Synonym: Dificid, Dificlir
Application: A macrocyclic antibiotic
CAS Number: 873857-62-6
Purity: ≥98%
Molecular Weight: 1058.04
Molecular Formula: C52H74Cl2O18
* Refer to Certificate of Analysis for lot specific data (including water content).
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Fidaxomicin is a recently approved antibiotic with a confusing history dating back to its original isolation in 1975. Fidaxomicin is the major analogue of a family of macrocyclic lactones isolated independently by three different groups from cultures belonging to three different genera (Actinoplanes, Dactylosporangium and Micromonospora) known as lipiarmycin A3, tiacumicin B and clostomicin B1, respectively. Fidaxomicin is a narrow spectrum antibiotic that works by inhibiting bacterial RNA polymerase and demonstrates excellent activity against Gram positive bacteria, notably Clostridium difficile. Fidaxomicin acts in the gastrointestinal tract without undue disruption to gut microbial flora.

Physical State :
Solid
Derived From :
Dactylosporum aurantiacum
Solubility :
Soluble in ethanol, methanol, DMF, DMSO, and Limited water solubility.
Storage :
Store at -20° C
Boiling Point :
~1046.4° C at 760 mmHg (Predicted)
Density :
~1.3 g/cm3 (Predicted)
Refractive Index :
n20D 1.59 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
46174142
SMILES :
CC[C@H]1/C=C(\[C@H](C/C=C/C=C(/C(=O)O[C@@H](C/C=C(/C=C(/[C@@H]1O[C@H]2[C@H]([C@H]([C@@H](C(O2)(C)C)OC(=O)C(C)C)O)O)\C)\C)[C@@H](C)O)\CO[C@H]3[C@H]([C@H]([C@@H]([C@H](O3)C)OC(=O)C4=C(C(=C(C(=C4O)Cl)O)Cl)CC)O)OC)O)/C

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Fidaxomicin  Product Citations

See how others have used Fidaxomicin. Click on the entry to view the PubMed entry .

Citations 1 to 2 of 2 total

PMID: # 28533232  Corbett, D. et al. 2017. Antimicrob. Agents Chemother.

PMID: # 25652750  Corbett, D. et al. 2015. J. Antimicrob. Chemother. 70: 1751-6.

Citations 1 to 2 of 2 total
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Rated 5 out of 5 by from Sachdeva Sachdeva, M. et al. (PubMed 25512411) tested Fidaxomicin, an RNA synthesis inhibitor and recently approved antibiotic, on Clostridium difficile cultures. Fidaxomicin led to strain-dependent effects on toxin production, including decreased toxin levels after treatment with subinhibitory concentrations, and more rapid declines in toxin production than in inhibition of colony formation. -SCBT Publication Review
Date published: 2015-01-18
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