Fidaxomicin is a recently approved antibiotic with a confusing history dating back to its original isolation in 1975. Fidaxomicin is the major analogue of a family of macrocyclic lactones isolated independently by three different groups from cultures belonging to three different genera (Actinoplanes, Dactylosporangium and Micromonospora) known as lipiarmycin A3, tiacumicin B and clostomicin B1, respectively. Fidaxomicin is a narrow spectrum antibiotic that works by inhibiting bacterial RNA polymerase and demonstrates excellent activity against Gram positive bacteria, notably Clostridium difficile. Fidaxomicin acts in the gastrointestinal tract without undue disruption to gut microbial flora.
See how others have used Fidaxomicin. Click on the entry to view the PubMed entry .
PMID: # 28533232 Corbett, D. et al. 2017. Antimicrob. Agents Chemother.
PMID: # 25652750 Corbett, D. et al. 2015. J. Antimicrob. Chemother. 70: 1751-6.
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