Fibronectin Inhibitor A tetrapeptide that supports fibroblast attachment and inhibits fibronectin binding

Fibronectin Inhibitor (CAS 91037-65-9)

Fibronectin Inhibitor | CAS 91037-65-9 is rated 5.0 out of 5 by 1.
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Synonym: Fibronectin tetrapeptide; H-Arg-Gly-Asp-Ser-OH
Application: A tetrapeptide that supports fibroblast attachment and inhibits fibronectin binding
CAS Number: 91037-65-9
Purity: ≥97%
Molecular Weight: 433.40
Molecular Formula: C15H27N7O8
* Refer to Certificate of Analysis for lot specific data (including water content).
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Fibronectin Inhibitor is a tetrapeptide which supports fibroblast attachment and inhibits fibronectin binding to platelets. Also an integrin binding sequence that inhibits integrin receptor function. Has been shown to decrease systemic inflammation via inhibition of collagen-triggered activation of leukocytes and attenuates expression of inflammatory cytokines, iNOS and MMP-9. Has been also shown to promote cell attachment and abrogates apoptosis via the mitochondrial pathway in osteoblasts in vitro . Known to be a target sequence for syphilis spirochete adherence.


References

1. Pierschbacher, M.D., et al. 1984. Nature. 309: 30-33. PMID: 6325925
2. Haverstick, D.M., et al. 1985. Blood. 66: 946-952. PMID: 3876125
3. Ginsberg, M., et al. 1985. J. Biol. Chem. 260: 3931-3936. PMID: 3980461
4. Thomas, D.D., et al. 1985. J. Exp. Med. 162: 1715-1719. PMID: 3903025
5. Perlot, R.L., et al. 2002. J. Bone Miner. Res. 17: 66-76. PMID: 11771671
6. Grigoriou, V., et al. 2005. J. Biol. Chem. 280: 1733-1739. PMID: 15522882
7. Droppelmann, C.A., et al. 2009. J. Biol. Chem. 284: 13551-13561. PMID: 19276073
8. Moon, C., et al. 2009. Respir. Res. 10: 18. PMID: 19272161

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in water (1 mg/ml), yielding a clear, colorless solution.
Storage :
Store at -20° C
Melting Point :
349.84° C (Predicted)
Density :
~1.7 g/cm3 (Predicted)
Refractive Index :
n20D 1.66 (Predicted)
IC50 :
Integrin beta-3: IC50 = 0.18 µM (human); Integrin alpha-IIb: IC50 = 0.18 µM (human); Fibronectin receptor alpha: IC50 = 2.2 µM (human); Fibronectin receptor beta: IC50 = 2.2 µM (human)
pK Values :
pKa: 2.85 (Predicted), pKb: 13.38 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
107775
MDL Number :
MFCD00076452
SMILES :
C(C[C@@H](C(=O)NCC(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CO)C(=O)O)N)CN=C(N)N

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Certificate of Analysis

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Fibronectin Inhibitor  Product Citations

See how others have used Fibronectin Inhibitor. Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 8416943  Heemskerk, JW. et al. 1993. J. Biol. Chem. 268: 356-363.

Citations 1 to 1 of 1 total

Hello, I want to buy a mouse fibronectin inhibitor. I think the one available in the website is Fibronectin Inhibidor (CAS 91037-65-9), does it only inhibit human fibronectin? Are there some analyses performing its effect on mouse fibronectin? thanks

Asked by: Luna Sánchez
Thank you for your message. You can check for further details the publications related to this product: 1. Pierschbacher, M.D., et al. 1984. Nature. 309: 30-33. PMID: 6325925 2. Haverstick, D.M., et al. 1985. Blood. 66: 946-952. PMID: 3876125 3. Ginsberg, M., et al. 1985. J. Biol. Chem. 260: 3931-3936. PMID: 3980461 4. Thomas, D.D., et al. 1985. J. Exp. Med. 162: 1715-1719. PMID: 3903025 5. Perlot, R.L., et al. 2002. J. Bone Miner. Res. 17: 66-76. PMID: 11771671 6. Grigoriou, V., et al. 2005. J. Biol. Chem. 280: 1733-1739. PMID: 15522882 7. Droppelmann, C.A., et al. 2009. J. Biol. Chem. 284: 13551-13561. PMID: 19276073 8. Moon, C., et al. 2009. Respir. Res. 10: 18. PMID: 19272161 If you require further help, please contact our Technical Service by phone or email or by Live Chat.
Answered by: SCBT Heidelberg Support
Date published: 2018-11-27
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Rated 5 out of 5 by from Heemskerk et al Heemskerk et al. (PubMed ID 8416943) added fibronectin inhibitor (H-Arg-Gly-Asp-Ser-OH) to a resuspension buffer used to prepare platelets for immobilization. -SCBT Publication Review
Date published: 2015-03-25
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