FGF Receptor Tyrosine Kinase Inhibitor A cell-permeable compound that acts as an ATP-competitive inhibitor of FGFR

FGF Receptor Tyrosine Kinase Inhibitor (CAS 192705-79-6)

FGF Receptor Tyrosine Kinase Inhibitor | CAS 192705-79-6 is rated 5.0 out of 5 by 1.
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Synonym: PD-166866; 1-[2-Amino-6-(3,5-dimethoxyphenyl)-pyrido[2,3-d]pyrimidin-7-yl]-3-tert-butyl urea
Application: A cell-permeable compound that acts as an ATP-competitive inhibitor of FGFR
CAS Number: 192705-79-6
Purity: ≥97%
Molecular Weight: 396.4
Molecular Formula: C20H24N6O3
* Refer to Certificate of Analysis for lot specific data (including water content).
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A cell-permeable pyridopyrimidinyl urea compound that acts a strong, ATP-competitive inhibitor of FGFR with excellent selectivity over EGFR, insulin receptor, PDGFRβ and c-Src


References

Panek, R.L., et al. 1998. J. Pharm. Exp. Ther. 286, 569. Hamby, J.M., et al. 1997. J. Med. Chem. 40, 2296.

Physical State :
Solid
Solubility :
Soluble in DMSO (10 mg/ml).
Storage :
Store at 4° C
Melting Point :
291-293° C
Boiling Point :
604.48° C (Predicted)
Density :
1.28 g/cm3 (Predicted)
Refractive Index :
n20D 1.64 (Predicted)
IC50 :
FGFR1: IC50 = 60 nM; c-Src : IC50 = >50 µM; FGFR3: IC50 = 60 nM (human); HUVEC50 : IC50 = 100 nM (human)
pK Values :
pKa: 10.15 (Predicted), pKb: 2.95 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
1
PubChem CID :
5328127
MDL Number :
MFCD12922514
SMILES :
CC(C)(C)NC(=O)NC1=C(C=C2C=NC(=NC2=N1)N)C3=CC(=CC(=C3)OC)OC

Download SDS (MSDS)

Certificate of Analysis

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Rated 5 out of 5 by from Works well I have tested expensive one, but it works equally well
Date published: 2016-12-16
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