Ferutinin is a potent, naturally occurring non-steroid estrogenic compound. It is an agonist for the estrogen receptor-α (ER alpha) and agonist/antagonist for ERβ with higher binding affinity than tamoxifen for both ERs. It is also suggested as a modest acetylcholinesterase (AChE) inhibitor.
Ferutinine structure: A.I. Saidkhodjaev, et al.; Chem. Nat. Comp. 1, 28 (1973) Ionophoretic properties of ferutinin: M.V. Zamaraeva, et al.; Cell Calcium 22, 235 (1997) Influence of plant terpenoids on the permeability of mitochondria and lipid bilayers: A.Y. Abramov, et al.; Biochim. Biophys. Acta 1512, 98 (2001) Daucane phytoestrogens: a structure-activity study: G. Appendino, et al.; J. Nat. Prod. 65, 1612 (2002) Terpenoids found in the umbelliferae family act as agonists/antagonists for ER(alpha) and ERbeta: differential transcription activity between ferutinine-liganded ER(alpha) and ERbeta: K. Ikeda, et al.; BBRC 291, 354 (2002) Actions of ionomycin, 4-BrA23187 and a novel electrogenic Ca2+ ionophore on mitochondria in intact cells: A.Y. Abramov & M.R. Duchen; Cell Calcium 33, 101 (2003)
See how others have used Ferutinin. Click on the entry to view the PubMed entry .
PMID: # 25260197 Delfosse, V. et al. 2014. Environ. Health Perspect. 122: 1306-13.
PMID: # 25106122 Pinto, C. et al. 2014. Toxicol. Appl. Pharmacol. 280: 60-9.
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