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Fenofibrate is a hypolipidemic compound which acts as a peroxisome proliferator-activated receptor α (PPARα) agonist (EC50 = 18 μM for mouse and EC50 = 30 μM for human). Fenofibrate also binds to PPARγ with at least 10-fold less affinity, and is inactive at PPARδ at concentrations up to 100 μM.
Inhibition of membrane-bound hepatic 3 hydroxy-3 methyl glutaryl CoA reductase as the consequence of altered membrane fluidity: E. Wulfert, et al.; Artery 9, 120 (1981) Fenofibrate protects lipoproteins from lipid peroxidation: synergistic interaction with alpha-tocopherol: E. Chaput, et al.; Lipids 34, 497 (1999) Effects of chronic treatment with statins and fenofibrate on rat skeletal muscle: a biochemical, histological and electrophysiological study: S. Pierno, et al.; Br. J. Pharmacol. 149, 909 (2006) In vitro and in vivo effects of the PPAR-alpha agonists fenofibrate and retinoic acid in endometrial cancer: S.A. Saidi, et al.; Mol. Cancer 5, 13 (2006) PPARalpha agonist fenofibrate suppresses tumor growth through direct and indirect angiogenesis inhibition: D. Panigrahy, et al.; PNAS 105, 985 (2008)
See how others have used Fenofibrate. Click on the entry to view the PubMed entry .
PMID: # 26872613
Rotondi, S. et al. 2016. Expression of Peroxisome Proliferator-Activated Receptor alpha (PPARα) in somatotropinomas: Relationship with Aryl hydrocarbon receptor Interacting Protein (AIP) and in vitro effects of fenofibrate in GH3 cells. Mol. Cell. Endocrinol..
PMID: # 26617775
Zuo, N. et al. 2015. Fenofibrate, a PPARα agonist, protect proximal tubular cells from albumin-bound fatty acids induced apoptosis via the activation of NF-kB. Int J Clin Exp Pathol. 8: 10653-61.
PMID: # 25881202
Ann, SJ. et al. 2015. PPARα agonists inhibit inflammatory activation of macrophages through upregulation of β-defensin 1. Atherosclerosis. 240: 389-97.
PMID: # 23747828
Petrescu, AD. et al. 2013. High glucose potentiates L-FABP mediated fibrate induction of PPARα in mouse hepatocytes. Biochim. Biophys. Acta. 1831: 1412-25.
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