Fascaplysin was originally isolated from a marine sponge and is involved in signal transduction and dna synthesis. Selective CDK4/cyclin D1 (IC50 = 350 nM) inhibitor (in an ATP competitive manner). Fascaplysin is an inhibitor of Cdk6.
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See how others have used Fascaplysin. Click on the entry to view the PubMed entry .
PMID: # 28922657 Jemaà, M. et al. 2017. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. 43: 431-444.
PMID: # 27626793 Mischitelli, M. et al. 2016. Cell. Physiol. Biochem. 39: 1638-47.
PMID: # 26569265 Ampofo, E. et al. 2015. Mar Drugs. 13: 6774-91.
PMID: # 26370090 Lee, JG. et al. 2015. J. Biol. Chem. 290: 26752-64.
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