Eugenol An antifungal antimicrobial agonist of the TRPV1 receptor

Eugenol (CAS 97-53-0)

Eugenol | CAS 97-53-0 is rated 5.0 out of 5 by 1.
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Synonym: 4-Allyl-2-methoxyphenol
Application: An antifungal antimicrobial agonist of the TRPV1 receptor
CAS Number: 97-53-0
Molecular Weight: 164.2
Molecular Formula: C10H12O2
* Refer to Certificate of Analysis for lot specific data (including water content).
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Eugenol is a small molecule with structural analogy to Capsaicin (sc-3577) that demonstrates agonism of the TRPV1 receptor. Eugenol is described to activate inward currents at the TRPV1, and this action is antagonized by the Capsaicin antagonist Capsazepine (sc-201098). Agonism of the TRPV1 by Eugenol has been correlated with an anesthetic effect. Eugenol also demonstrates antifungal and antimicrobial activity, showing efficacy against Candida albicans biofilms, Listeria monocytogenes and Escherichia coli. Eugenol is further described to induce reactive oxygen species (ROS) production and to scavenge ROS, thus demonstrating prooxidant and antioxidant effects.


References

1. Fujisawa, S., et al. 2002. Toxicology. 177: 39-54. PMID: 12126794
2. Yang, B.H., et al. 2003. J. Dent. Res. 82: 781-785. PMID: 14514756
3. Atsumi, T., et al. 2005. Toxicol In Vitro. 19: 1025-1033. PMID: 15964168
4. Guenette, S.A., et al. 2006. J. Vet. Pharmacol. Ther. 29: 265-270. PMID: 16846463
5. Gaysinsky, S., et al. 2007. J. Food Prot. 70: 2631-2637. PMID: 18044447
6. He, M., et al. 2007. Mycopathologia. 163: 137-143. PMID: 17356790
7. Park, C.K., et al. 2009. Pain. 144: 84-94. PMID: 19376653

Physical State :
Liquid
Solubility :
Soluble in 100% ethanol, ether, oils, 70% alcohol, glacial acetic acid, chloroform, and aqueous sodium hydroxide. Insoluble in water.
Storage :
Store at 4° C
Melting Point :
-12--10° C (lit.)
Boiling Point :
254° C (lit.)
Density :
1.07 g/mL at 25° C (lit.)
Refractive Index :
n20D 1.54
IC50 :
Androgen Receptor: IC50 = 19 µM (human); Cyclooxygenase-1: IC50 = 11 µM (human)
pK Values :
pKa: 10.19 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
SJ4375000
PubChem CID :
3314
Merck Index :
14: 3898
MDL Number :
MFCD00008654
EC Number :
202-589-1
Beilstein Registry :
1366759
SMILES :
COC1=C(C=CC(=C1)CC=C)O

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Certificate of Analysis

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Since it is in a liquid state, what solvent used?

Asked by: SCchem16
Thank you for your question. This chemical, Eugenol (CAS 97-53-0), is provided in it's pure form. Eugenol has a melting point of roughly -10 ºC which is why at room temperature it will be in a liquid state.
Answered by: Chemical Support 2
Date published: 2018-07-10

i want to use eugenol for invitro assay but for concentration i need it it in solid form how can i use eugenol that is in liquid form

Asked by: Suman
Thank you for your question. We are not able to provide you with the usage information you requested for this chemical, Eugenol (CAS 97-53-0). This information may be available in the literature, and we have 7 journal articles listed as references for this chemical on our website. Please find the references below the ordering information table, with the product description.
Answered by: Technical Support
Date published: 2016-12-28
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Rated 5 out of 5 by from Park et al Park et al. (PubMed ID 19376653) found that eugenol inhibited the voltage-gated sodium channel (VGSC) and activation of transient receptor potential vanilloid subtype 1 (TRPV1),in trigeminal ganglion (TG) neurons. -SCBT Publication Review
Date published: 2015-05-10
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