Etoposide Phosphate A topoisomerase II inhibitor inspired by podophyllotoxin

Etoposide Phosphate (CAS 117091-64-2)

Etoposide Phosphate | CAS 117091-64-2 is rated 5.0 out of 5 by 1.
  • y_2019, m_7, d_16, h_16
  • bvseo_bulk, prod_bvrr, vn_bulk_2.0.12
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_357357, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 73ms
  • REVIEWS, PRODUCT
Synonym: Eposin; Etopophos; Vepesid; VP-16
Application: A topoisomerase II inhibitor inspired by podophyllotoxin
CAS Number: 117091-64-2
Purity: ≥98%
Molecular Weight: 668.53
Molecular Formula: C29H33O16P
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

Etoposide Phosphate is a derivative of Etoposide (VP-16) (sc-3512). Etoposide is a topoisomerase II inhibitor that is widely used as an apoptosis inducer. Etoposide exhibits antineoplastic and anti-mitotic properties. Inhibits DNA synthesis and induces double-strand and single-strand DNA breaks. Cell-cycle dependent and cell-cycle specific to late S and G2 phases. Activates p53 resulting in upregulated expression of TRAIL-R2 (DR5) and Bak to overcome TRAIL resistance in Bax-deficient human colon carcinoma cancer cells. Etoposide Phosphate is an activator of p53.

Appearance :
Crystalline powder
Physical State :
Solid
Solubility :
Soluble in cold water (easily).
Storage :
Store at room temperature
Density :
~1.64 g/cm3 (Predicted)
Refractive Index :
n20D ~1.66 (Predicted)
IC50 :
Topoisomerase 2: IC50 = 59.2 µM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
6918092
Merck Index :
14: 3886
MDL Number :
MFCD00270859
SMILES :
C[C@@H]1OC[C@@H]2[C@@H](O1)[C@@H]([C@H]([C@@H](O2)O[C@H]3[C@H]4COC(=O)[C@@H]4[C@@H](C5=CC6=C(C=C35)OCO6)C7=CC(=C(C(=C7)OC)OP(=O)(O)O)OC)O)O

Download SDS (MSDS)

Certificate of Analysis

Adobe Acrobat Reader is required to reliably view,
print and comment on PDF documents

Etoposide Phosphate  Product Citations

See how others have used Etoposide Phosphate. Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 26416623  Lehouritis, P. et al. 2015. Sci Rep. 5: 14554.

Citations 1 to 1 of 1 total
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 66ms
  • QUESTIONS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
Rated 5 out of 5 by from Many articles reported Etoposide Phosphate Many articles reported Etoposide Phosphate, a derivative of etoposide, to be a topoisomeras II inhibitor, and induce apoptosis in some cancers. -SCBT Publication Review
Date published: 2015-02-23
  • y_2019, m_7, d_16, h_16
  • bvseo_bulk, prod_bvrr, vn_bulk_2.0.12
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_357357, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 9ms
  • REVIEWS, PRODUCT

Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2019 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.