Etidronate Disodium A bisphosphonate bone resorption inhibitor

Etidronate Disodium (CAS 7414-83-7)

Etidronate Disodium | CAS 7414-83-7 is rated 5.0 out of 5 by 1.
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Synonym: Didronel; Diphos
Application: A bisphosphonate bone resorption inhibitor
CAS Number: 7414-83-7
Purity: ≥98%
Molecular Weight: 249.99
Molecular Formula: C2H6O7P22Na
* Refer to Certificate of Analysis for lot specific data (including water content).
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Etidronate Disodium is a bisphosphonate bone resorption inhibitor. Phosphonate ligands demonstrate a very high affinity for alkali metal ions and form crystals with some difficulty. Organophosphonate chelating compounds are able to prevent precipitation of calcium salts at stoichiometric concentrations which is applicable in corrosion inhibition, water treatment and scale inhibition. Etidronate Disodium is an inhibitor of FDPS.

Physical State :
Solid
Solubility :
Soluble in water (26 mg/ml).
Storage :
Store at 4° C
Melting Point :
>300° C
Refractive Index :
n20D 1.59 (Predicted)
IC50 :
Phosphatidylinositol 3-kinase: IC50 >50 µM (bovine); Farnesyl diphosphate synthase : IC50 = 80 µM; bone resorption: IC50 = 100 µM (avian osteoclast); Inositol-1(or 4)-monophosphatase 1: IC50 = 110 µM (bovine); Dictyostelium discoideum: IC50 = 380 µM
Ki Data :
Escherichia coli F plasmid TraI relaxase Y16F mutant: Ki= 3 nM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
23894
Merck Index :
14: 3863
MDL Number :
MFCD00152567
EC Number :
231-025-7
SMILES :
CC(O)(P(=O)(O)[O-])P(=O)(O)[O-].[Na+].[Na+]

Download SDS (MSDS)

Certificate of Analysis

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What is the appearance of the compound?

Asked by: two2igm05
Thank you for your question. Etidronate Disodium, sc-205687, is a white solid.
Answered by: TechService7
Date published: 2017-01-27
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Rated 5 out of 5 by from Li et al Li et al. (Pubmed ID 25607347) found that Etidronate Disodium significantly reduced ectopic soft tissue mineralization caused by ABCC6 gene mutations. -SCBT Publication Review
Date published: 2015-02-05
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