Erythromycin A macrolide antibiotic protein synthesis inhibitor

Erythromycin (CAS 114-07-8)

Erythromycin | CAS 114-07-8 is rated 5.0 out of 5 by 2.
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Synonym: Abomacetin
Application: A macrolide antibiotic protein synthesis inhibitor
CAS Number: 114-07-8
Purity: ≥92%
Molecular Weight: 733.9
Molecular Formula: C37H67NO13
* Refer to Certificate of Analysis for lot specific data (including water content).
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Erythromycin is a potent macrolide inhibitor of CYP3A4 with antiinflammatory and prokinetic properties. Macrolides belong to a group of antibiotics that bind to the 50S ribosomal subunit and inhibit protein synthesis. Erythromycin is derived from Streptomyces erythreus and has been shown to inhibit NF-κB transcriptional activation, which leads to the inhibition of cytokine gene expression of IL-8 and lL-6. This mechanism was shown to occur via calcineruin-independent signaling T lymphocytes.


References

1. Weisblum, B. 1984. Br. Med. Bull. 40: 47-53. PMID: 6442874
2. Aoki, Y., et al. 1999. Antimicrob. Agents Chemother. 43: 2678-2684. PMID: 10543746
3. Tran, J.Q., et al. 1999. J Clin Pharmacol. 39: 513-519. PMID: 10234600
4. Tokairin, T., et al. 2005. Br J Clin Pharmacol. 60: 172-175. PMID: 16042670
5. Berthet, S., et al. 2010. J Visc Surg. 147: e13-e18. PMID: 20655290

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in 2 M HCl (50 mg/ml), ethanol, water (50 mg/ml), methanol, and chloroform.
Storage :
Store at -20° C
Melting Point :
135-140° C (lit.)
Boiling Point :
818.4° C at 760 mmHg (Predicted)
Density :
1.2 g/cm3 (Predicted)
Refractive Index :
n20D 1.54 (Predicted)
Optical Activity :
α20D -75.8°, c = 2 in ethanol
pK Values :
pKa: 8.8 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
KF4375000
PubChem CID :
16212992
Merck Index :
14: 3681
MDL Number :
MFCD00084654
EC Number :
204-040-1
Beilstein Registry :
75279
SMILES :
CC[C@@H]1[C@@](C([C@H](C(=O)[C@@H](C[C@@](C(C(C([C@H](C(=O)O1)C)O[C@H]2C[C@@]([C@H]([C@@H](O2)C)O)(C)OC)C)OC3[C@@H]([C@H](C[C@H](O3)C)N(C)C)O)(C)O)C)C)O)(C)O

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Certificate of Analysis

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Erythromycin  Product Citations

See how others have used Erythromycin. Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 29145161  Xie, W. et al. 2017. Ecotoxicol. Environ. Saf. 149: 10-18.

Citations 1 to 1 of 1 total

What is the appearance of the chemical?

Asked by: two2igm05
Thank you for your question. The compound, sc-204742, is provided as a white powder. If you have any further questions or concerns, please feel free to contact our Technical Service department by calling 800-457-3801 option 2, emailing scbt@scbt.com, or using the Live Chat function on our website.
Answered by: Tech Service 8
Date published: 2017-01-23
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Rated 5 out of 5 by from Use this regularly in our lab and works well Use this regularly in our lab and works well.
Date published: 2015-09-23
Rated 5 out of 5 by from Tokairin et al Tokairin et al. (PubMed ID 16042670) used erythromycin to increase peak plasma concentration of brotizolam to study cytochrome P450 involvement in the metabolism of brotizolam. -SCBT Publication Review
Date published: 2015-03-22
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