ERK Inhibitor A cell-permeable thiazolidinedione compound that shows anti-proliferative properties

ERK Inhibitor (CAS 1049738-54-6)

ERK Inhibitor | CAS 1049738-54-6 is rated 5.0 out of 5 by 1.
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Synonym: 3-(2-Aminoethyl)-5-((4-ethoxyphenyl)methylene)-2,4-thiazolidinedione, HCl
Application: A cell-permeable thiazolidinedione compound that shows anti-proliferative properties
CAS Number: 1049738-54-6
Purity: ≥95%
Molecular Weight: 328.81
Molecular Formula: C14H16N2O3S•HCl
* Refer to Certificate of Analysis for lot specific data (including water content).
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ERK Inhibitor is a cell-permeable thiazolidinedione compound that shows anti-proliferative properties. Binds preferentially to ERK2 with a KD of ~5 μM and prevents its interaction with protein substrates. The compound has been shown to block ERK-mediated phosphorylation of ribosomal S6 kinase-1 (RSK-1) and ternary complex factor Elk-1 in HeLa cells, while exhibiting minimal effect on ERK1/2 phosphorylation by MEK1/2.


References

1. Hancock, C.N., et al. 2005. J. Med. Chem. 48: 4586-4595. PMID: 15999996

Physical State :
Solid
Solubility :
Soluble in DMSO (≥4 mg/mL).
Storage :
Store at 4° C
Refractive Index :
n20D ~1.65 (Predicted)
IC50 :
HeLa: IC50 = ≤ 25 µM; A549: IC50 = ≤ 25 µM; SUM-159 tumor cells: IC50 = ≤ 25 µM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
16218944
MDL Number :
MFCD09038681
SMILES :
CCOC1=CC=C(C=C1)C=C2C(=O)N(C(=O)S2)CCN.Cl

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Certificate of Analysis

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ERK Inhibitor  Product Citations

See how others have used ERK Inhibitor. Click on the entry to view the PubMed entry .

Citations 1 to 4 of 4 total

PMID: # 27959384  Fujii, K. et al. 2017. Int. J. Oncol. 50: 85-92.

PMID: # 27129263  Wu, Y. et al. 2016. J. Biol. Chem. 291: 12370-82.

PMID: # 25778866  Lee, JS. et al. 2015. Biochemical and biophysical research communications. 460: 267-73.

PMID: # 23278864  Lu, J. et al. 2013. J Anim Physiol Anim Nutr (Berl). 97: 1170-8.

Citations 1 to 4 of 4 total
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Rated 5 out of 5 by from Winiarska Winiarska, K. et al. (PubMed 25601753) used the ERK Inhibitor (3-(2-Aminoethyl)-5-((4-ethoxyphenyl)methylene)-2,4-thiazolidinedione) to demonstrate that ERK1/2 pathway is involved in renal gluconeogenesis inhibition under conditions of lowered NADPH oxidase activity. -SCBT Publication Review
Date published: 2015-05-15
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