ERK Inhibitor is a cell-permeable thiazolidinedione compound that shows anti-proliferative properties. Binds preferentially to ERK2 with a KD of ~5 μM and prevents its interaction with protein substrates. The compound has been shown to block ERK-mediated phosphorylation of ribosomal S6 kinase-1 (RSK-1) and ternary complex factor Elk-1 in HeLa cells, while exhibiting minimal effect on ERK1/2 phosphorylation by MEK1/2.
1. Hancock, C.N., et al. 2005. J. Med. Chem. 48: 4586-4595. PMID: 15999996
See how others have used ERK Inhibitor. Click on the entry to view the PubMed entry .
PMID: # 27959384 Fujii, K. et al. 2017. Int. J. Oncol. 50: 85-92.
PMID: # 27129263 Wu, Y. et al. 2016. J. Biol. Chem. 291: 12370-82.
PMID: # 25778866 Lee, JS. et al. 2015. Biochemical and biophysical research communications. 460: 267-73.
PMID: # 23278864 Lu, J. et al. 2013. J Anim Physiol Anim Nutr (Berl). 97: 1170-8.
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