Epac (H-70) will be discontinued December 31, 2016; to receive a 10 µg sample of Epac (A-5): sc-28366, our highly recommended and much superior monoclonal antibody alternative to this product, please contact Technical Service.
Epac Activators for functional analysis of cellular responses to Epac
Every item is shipped based on the best shipping method assessed for the temperature requirements of that specific item. Items are grouped and shipped together whenever
possible, and a separate shipping charge will be included for each shipping method required. Shipping charges listed below are from our US warehouses to the Contiguous US,
Alaska, Hawaii, Canada and Puerto Rico. Shipping charges for countries outside the US and Canada will be determined once order has been received
Please note: We can not ship to PO boxes
Express Blue Ice
Express Dry Ice
Animal Health Prescription Item
SHIPPING METHODS & CHARGES
Ships via FedEx Ground to Contiguous US, Alaska, Canada, Monday through Friday. This method is used for less temperature sensitive items such as lab ware and animal
health products, bulky and/or heavy items
Labware ships FedEx Ground free of charge to the contiguous US
3',5' cyclic adenosine monophosphate (cAMP)-regulated guanine nucleotide exchange factors Epac (Epac1, cAMP-GEFI) and Epac2 (cAMP-GEFII) activate the Ras family GTPases Rap 1 and Rap 2 by promoting GTP binding in a cAMP-dependent manner. Eukaryotic cAMP is a second messenger that induces physiological responses such as gene expression, growth, differentiation, secretion and neurotransmission. The human Epac gene maps to chromosome 12q13.11 with transcript being abundant in the kidney and heart. In situ hybridization indicates expression of Epac in adult rat brain and selective expression in neonatal brain, including septum and thalamus.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PMID: # 21047789 Hochbaum, D. et al. 2011. Radixin assembles cAMP effectors Epac and PKA into a functional cAMP compartment: role in cAMP-dependent cell proliferation. J. Biol. Chem.. 286: 859-866.
PMID: # 20547757 Liu, C. et al. 2010. The interaction of Epac1 and Ran promotes Rap1 activation at the nuclear envelope. Mol. Cell. Biol.. 30: 3956-3969.
PMID: # 18728186 Huston, E. et al. 2008. EPAC and PKA allow cAMP dual control over DNA-PK nuclear translocation. Proc. Natl. Acad. Sci. U.S.A.. 105: 12791-12796.
PMID: # 18687752 Masyuk, AI. et al. 2008. Cholangiocyte primary cilia are chemosensory organelles that detect biliary nucleotides via P2Y12 purinergic receptors. Am. J. Physiol. Gastrointest. Liver Physiol.. 295: G725-G734.
PMID: # 17725712 Potapova, IA. et al. 2007. Voltage-gated ion channel Kv4.3 is associated with Rap guanine nucleotide exchange factors and regulates angiotensin receptor type 1 signaling to small G-protein Rap. FEBS J.. 274: 4375-4384.
PMID: # 16177794 Dodge-Kafka KL et al. 2005. The protein kinase A anchoring protein mAKAP coordinates two integrated cAMP effector pathways Nature. 437(7058): 574-578.
PMID: # 15987941 Hucho TB, et al. 2005. Epac mediates a cAMP-to-PKC signaling in inflammatory pain: an isolectin B4(+) neuron-specific mechanism.
J Neurosci.. 25(26): 6119-6126.
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