Enrofloxacin An antibiotic that acts against gram-positive and -negative bacteria

Enrofloxacin (CAS 93106-60-6)

Enrofloxacin | CAS 93106-60-6 is rated 5.0 out of 5 by 1.
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Application: An antibiotic that acts against gram-positive and -negative bacteria
CAS Number: 93106-60-6
Purity: >98%
Molecular Weight: 359.39
Molecular Formula: C19H22FN3O3
* Refer to Certificate of Analysis for lot specific data (including water content).
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Enrofloxacin is an antibiotic derivative of quinolone carboxylic acid with broad spectrum activity against gram-positive and gram-negative bacteria, as well as Mycoplasma sp. Additionally, enrofloxacin inhibits Topo II α (DNA gyrase) and has been used to study quinolone resistance in the Salmonella enterica subspecies enterica serovar Choleraesuis, Mycoplasma gallisepticum and Escherichia coli.


References

1. Schroder, J., et al., 1989. Enrofloxacin: a new antimicrobial agent. Journal of the South African Veterinary Association. 60(2): 122-4. PMID: 2691696
2. Usui, Masaru., et al., 2009. Intracellular concentrations of enrofloxacin in quinolone-resistant Salmonella enterica subspecies enterica serovar Choleraesuis. International journal of antimicrobial agents. 34(6): 592-5. PMID: 19733466
3. Forcella, C., et al., 2010. Characterization of quinolone resistance in Escherichia coli strains of animal origin from Italy. Journal of chemotherapy (Florence, Italy). 22(3): 165-8. PMID: 20566420
4. Usui, Masaru., et al., 2011. Contribution of enhanced efflux to reduced susceptibility of Salmonella enterica serovar Choleraesuis to fluoroquinolone and other antimicrobials. The Journal of veterinary medical science / the Japanese Society of Veterinary Science. 73(2): 279-82. PMID: 20953129

Appearance :
Crystalline powder
Physical State :
Solid
Solubility :
Soluble in water (partly), DMF ( hot), ethanol (slightly), chloroform (slightly), and DMSO (1 mg/ml at 25° C).
Storage :
Store at 4° C
Melting Point :
218.9-221.1° C
Boiling Point :
560.46° C at 760 mmHg (Predicted)
Density :
1.39 g/cm3 (Predicted)
Refractive Index :
n20D 1.63 (Predicted)
IC50 :
Streptococcus: EC5050 = 1.04 µM; Streptokinase A: EC5050 = 1.29 µM (streptococcus pyogenes serotype M1)
pK Values :
pKa: 6.43 (Predicted), pKb: 7.76 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
VB1993650
PubChem CID :
71188
Merck Index :
14: 3592
MDL Number :
MFCD00792463
Beilstein Registry :
5307824
SMILES :
CCN1CCN(CC1)C2=C(C=C3C(=C2)N(C=C(C3=O)C(=O)O)C4CC4)F

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Certificate of Analysis

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Rated 5 out of 5 by from Badal Badal. et al. (PubMed ID 26205818) showed that Enrofloxacin was a powerful iron chelator that inhibited -ketoglutarate-dependent dioxygenases in HEK293 cells. -SCBT Publication Review
Date published: 2015-03-02
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