Enoxacin A quinolone antibacterial agent that acts on DNA gyrase

Enoxacin (CAS 74011-58-8)

Enoxacin | CAS 74011-58-8 is rated 4.5 out of 5 by 2.
  • y_2019, m_3, d_24, h_18
  • bvseo_bulk, prod_bvrr, vn_bulk_2.0.11
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_2
  • loc_en_US, sid_205670, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 40ms
  • REVIEWS, PRODUCT
Synonym: 1-Ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-1,8-naphthyridine-3-carboxylic acid; Abenox; Bactidan; Comprecin; Flumark; Penetrex
Application: A quinolone antibacterial agent that acts on DNA gyrase
CAS Number: 74011-58-8
Purity: ≥99%
Molecular Weight: 320.32
Molecular Formula: C15H17FN4O3
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

Enoxacin is a quinolone antibacteral agent. Acts on DNA gyrase.


References

1. Yoshida, H., et al. 1993. Antimicrob. Agents. Chemother. 37: 839-845. PMID: 8388200

Physical State :
Solid
Solubility :
Soluble in water (Partly), 1 M NaOH (50 mg/ml, Yellow, Clear to Slightly Hazy), DMSO (Sparingly), chloroform (Sparingly), and methanol (Sparingly).
Storage :
Store at room temperature
Melting Point :
220-224° C (lit.)
Boiling Point :
~569.87° C at 760 mmHg (Predicted)
Density :
~1.39 g/cm3 (Predicted)
Refractive Index :
n20D 1.60 (Predicted)
IC50 :
Mycobacterium tuberculosis DNA gyrase GyrB/GyrA M74I and A83S mutant: IC50 = 9 µM; V-ATPase B2: IC50 = 10 µM (human); Mycobacterium tuberculosis DNA gyrase GyrB/GyrA A83S, S84A and I85V mutant: IC50 = 11 µM; Escherichia coli DNA gyrase GyrA/GyrB: IC50 = 14 µM; Mycobacterium tuberculosis DNA gyrase GyrB/GyrA A83S, S84A, I85V, F96W and P101M mutant: IC50 = 16 µM
pK Values :
pKa: 6.04 (Predicted), pKb: 8.19 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
2
RTECS :
QN2800000
PubChem CID :
3229
Merck Index :
14: 3587
MDL Number :
MFCD00133308
Beilstein Registry :
3628995
SMILES :
CCN1C=C(C(=O)C2=CC(=C(N=C21)N3CCNCC3)F)C(=O)O

Download SDS (MSDS)

Certificate of Analysis

Adobe Acrobat Reader is required to reliably view,
print and comment on PDF documents

Enoxacin  Product Citations

See how others have used Enoxacin. Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 28133512  Lee, YS. et al. 2017. Toxicol Res. 33: 43-48.

Citations 1 to 1 of 1 total

How much water should I add in order to get 100uM solution in the end? Would be good if you could attach anything like this in the documentation.

Asked by: Sarnai
Thank you for your question. Enoxacin: sc-205670 is soluble in water a concentration of <1 mg/mL warmed.
Answered by: Technical Support
Date published: 2017-02-16

What is the solubility of this product?

Asked by: hawkeye11
This product is soluble in DMSO <1 mg/mL; Water <1 mg/mL. Soluble to 100 mM in DMSO or in ethanol.
Answered by: Tech Service 4
Date published: 2016-12-16
  • y_2019, m_3, d_24, h_18CST
  • bvseo_bulk, prod_bvqa, vn_bulk_2.0.11
  • cp_1, bvpage1
  • co_hasquestionsanswers, tq_2
  • loc_en_US, sid_205670, prod, sort_[SortEntry(order=LAST_APPROVED_ANSWER_SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 42ms
  • QUESTIONS, PRODUCT
Rated 5 out of 5 by from Emde A; et al Emde A; et al. (PubMed ID: 26330466) determined that Enoxacin is beneficial for neuromuscular function via enhanced DICER activity. -SCBT Publication Review
Date published: 2015-04-20
Rated 4 out of 5 by from I will rate this product a 4 and rate 5 I will rate this product a 4 and rate 5 for your logistics, customer service and support.
Date published: 2015-04-20
  • y_2019, m_3, d_24, h_18
  • bvseo_bulk, prod_bvrr, vn_bulk_2.0.11
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_2
  • loc_en_US, sid_205670, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 229ms
  • REVIEWS, PRODUCT

Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2019 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.