Enniatin A A Fusarium produced depsipeptide ionophore

Enniatin A (CAS 2503-13-1)

Enniatin A | CAS 2503-13-1 is rated 5.0 out of 5 by 1.
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Application: A Fusarium produced depsipeptide ionophore
CAS Number: 2503-13-1
Purity: >99%
Molecular Weight: 681.9
Molecular Formula: C36H63N3O9
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Enniatins are a family of depsipeptides produced several Fusarium species. The enniatins have been shown to act as ionophores. More recently their effects on acyl-CoA cholesterol transferase, transporters and the selectivity of their antitumor action havereceived more focus. Enniatin A is one of four major analogues of the enniatin complex and has not previously been available for investigation.


References

1. Ionophore antibiotics produced by the fungus Fusarium orthoceras var. enniatum and other Fusaria. Gaumann E. et al., Experientia 1947, 3, 202. 2. "Sandwich" complexation in cyclopeptides and its implications in membrane processes. Ivanov V.T. Ann. N. Y. Acad. Sci. 1975, 264, 221. 3. Interaction of cyclic peptides and depsipeptides with calmodulin. Mereish K.A. et al., Pept. Res. 1990, 3, 233. 4. Enniatin has a new function as an inhibitor of Pdr5p, one of the ABC transporters in Saccharomyces cerevisiae. Hiraga K. et al., Biochem. Biophys. Res. Commun. 2005, 328, 1119. 5. Enniatin exerts p53-dependent cytostatic and p53-independent cytotoxic activities against human cancer cells. Dornetshuber R. et al., Chem. Res. Toxicol. 2007, 20, 465.

Physical State :
Solid
Derived From :
Fusarium sp.
Solubility :
Soluble in ethanol (10 mg/ml), methanol (10 mg/ml), DMSO (10 mg/ml), DMF, and water (partly).
Storage :
Store at -20° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
16727691
MDL Number :
MFCD19442801
SMILES :
CCCCC1C(=O)OC(C(=O)N(C(C(=O)OC(C(=O)N(C(C(=O)OC(C(=O)N1C)C(C)C)CCCC)C)C(C)C)C(C)CC)C)C(C)C

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Certificate of Analysis

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Enniatin A  Product Citations

See how others have used Enniatin A. Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 21621786  Frenich, AG. et al. 2011. J Chromatogr A. 1218: 4349-4356.

Citations 1 to 1 of 1 total
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Rated 5 out of 5 by from Juan Juan-Garcia et al. (Pubmed ID 26342765) found that enniatin A decreased the apoptotic-necrotic percentage of hepatocarcinoma cells (HepG2) and disrupted the MMP. -SCBT Publication Review
Date published: 2015-05-01
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