Enalaprilat dihydrateAn active metabolite of the ACE inhibitor, Enalapril

Enalaprilat dihydrate (CAS 84680-54-6)

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Application: An active metabolite of the ACE inhibitor, Enalapril
CAS Number: 84680-54-6
Purity: ≥98%
Molecular Weight: 384.42
Molecular Formula: C18H24N2O5 2H2O
* Refer to Certificate of Analysis for lot specific data (including water content).
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Enaprilat is the active metabolite of the compound Enalapril. Enalapril is an ACE (angiotensin-converting enzyme) inhibitor, suggested to be more potent than Captopril (sc-200566). The compound is reported to be converted to the active form, Enalaprilat (sc-205669), through hepatic hydrolysis. Enalapril downregulates the expression of IL-β, IL-6, and NK-κB. Enalaprilat dihydrate is an activator of bradykinin B1 R.


References

1. Kelly, J.G. and O'Malley, K. 1990. Clin Pharmacokinet. 19: 177-196. PMID: 2203579
2. Shioya, H., et al. 1992. Biomed. Chromatogr. 6: 59-62. PMID: 1322206
3. Lupi, R., et al. 2006. Eur. J. Endocrinol. 154: 355-361. PMID: 16452552
4. Wang, S.L., et al. 2010. Sichuan Da Xue Xue Bao Yi Xue Ban. 41: 1003-7, 1038. PMID: 21265103
5. Zhang, Y.H., et al. 2010. Sichuan Da Xue Xue Bao Yi Xue Ban. 41: 998-1002. PMID: 21265102
6. Yim, H.E., et al. 2011. Pediatr. Res. 69: 378-383. PMID: 21263376

Physical State :
Solid
Solubility :
Soluble in water (5 mg/ml at 25° C), ethanol (1 mg/ml at 25° C), DMSO (70 mg/ml at 25° C), methanol, and DMF.
Storage :
Store at room temperature
Melting Point :
151-159° C
Boiling Point :
601° C at 760 mmHg (Predicted)
Refractive Index :
n20D 1.58 (Predicted)
Optical Activity :
α20/D -48.4°, c = 0.5 in methanol
IC50 :
ACE: IC50 = 1.94 nM
Ki Data :
Angiotensin-converting enzyme-related carboxypeptidase: Ki= 0.5 nM; ACE: Ki= 1.4 nM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
TW3590600
Merck Index :
14: 3567
MDL Number :
MFCD00941393
EC Number :
278-459-3
SMILES :
CC(C(=O)N1CCCC1C(=O)O)NC(CCC2=CC=CC=C2)C(=O)O.O.O

Download SDS (MSDS)

Certificate of Analysis

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