Enalapril Maleate An angiotensin-converting enzyme inhibitor

Enalapril Maleate (CAS 76095-16-4)

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Application: An angiotensin-converting enzyme inhibitor
CAS Number: 76095-16-4
Purity: ≥98%
Molecular Weight: 492.52
Molecular Formula: C24H32N2O9
* Refer to Certificate of Analysis for lot specific data (including water content).
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Enalapril Maleate is an effective and potent nonsulfhydryl ACE(angiotenson-converting enzyme) inhibitor. The compound has been used to study diabetic angiopathy in diabetic rats and inhibition of ACE in hog plasma (I50=1.2nM). ACE inhibitors disturb the enin-angiotensin- aldosterone system. Additional ACE inhibitors include: Enalapril (sc-205664), Enalaprilat dihydrate (sc-205668), Enalaprilat (sc-205669), and Enalapril-d5 Maleate Salt (sc-218304), among others.


References

1. Tocco, D.J., et al. 1982. Drug Metab. Dispos. 10: 15-19. PMID: 6124377
2. Sweet, C.S. 1983. Fed. Proc. 42: 167-170. PMID: 6295819
3. Cleary, J.D. and Taylor, J.W. 1986. Drug Intell Clin Pharm. 20: 177-186. PMID: 3007062
4. Itoh, Y., et al. 2002. J. Endocrinol. 175: 233-239. PMID: 12379508

Physical State :
Solid
Solubility :
Soluble in water (25 mg/ml), methanol (50 mg/ml), and ethanol (8 mg/ml).
Storage :
Store at room temperature
Melting Point :
143-144° C
Optical Activity :
α25/D -42.2°, c = 1 in methanol
pK Values :
pKa: 3.0, 5.4, 3.15 (Predicted), pKb: 5.43 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
2
RTECS :
TW3666000
PubChem CID :
5388961
MDL Number :
MFCD00133304
EC Number :
278-375-7
SMILES :
OC(=O)\C=C/C(O)=O.CCOC(=O)[C@H](CCC1=CC=CC=C1)N[C@@H](C)C(=O)N1CCC[C@H]1C(O)=O

Download SDS (MSDS)

Certificate of Analysis

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