Embelin, a cell permeable 1,4-Benzoquinone (sc-202873)-derivative originally isolated from Embelia ribes, has been shown to contain antiproliferative characteristics in 3-Methylcholanthrene (sc-216516)-induced fibrosarcoma in albino rats. This compound has also been reported to be an antinociceptive and antiinflammatory agent. Additionally, Embelin has been found to display antibacterial potential against 3 strains of 12 bacteria. Other studies have reported Embelin to have apoptosis induction capabilities through binding of BIR3 domain of XIAP (X-linked inhibitor of apoptosis protein). The antioxidant capabilities of Embelin have also been studied and mechanistic studies suggest that Embelin has a tendency to scavenge DPPH (sc-202591) radicals and inhibit hydroxyl radical induced deoxyribose degradation. This compound prevents the activation of NF-κB by inhibiting IKK. Embelin is an inhibitor of PCAF and XIAP and an activator of caspase-9.
1. Chitra, M., et al. 1994. Chemotherapy. 40: 109-113. PMID: 7510605 2. Chitra, M., et al. 2003. Fitoterapia. 74: 401-403. PMID: 12781816 3. Nikolovska-Coleska, Z., et al. 2004. J. Med. Chem. 47: 2430-2440. PMID: 15115387 4. Joshi, R., et al. 2007. Chem. Biol. Interact. 167: 125-134. PMID: 17379198
Soluble in DMSO (>10 mg/ml), methanol, ethanol (10 mM), and chloroform. Insoluble in water.
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Rated 5 out of
Date published: 2015-10-08
Rated 5 out of
HuangHuang, et. al. (PubMed ID 23749209) treated HCT116 cells with Embelin (purchased from SCBT) and found that it enhanced both conversion of LC3-I to LC3-II and formation of GFP-LC3 puncta in a dose and time dependent manner. However, it failed to enhance autophagy in HCT116 XIAP KO cells. -SCBT Publication Review
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