Eicosa-11Z,14Z-dienoic acid is a polyunsaturated lipid analog of arachidonic acid. It has been shown to inhibit calcineurin.
Carbohydrates and Lipids
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A polyunsaturated lipid analog of arachidonic acid that inhibits calcineurin
20H 36O 2 *
Certificate of Analysis for lot specific data (including water content).
Eicosa-11Z,14Z-dienoic acid is a polyunsaturated lipid analog of arachidonic acid. It has been shown to inhibit PP2 (calcineurin), a protein phosphatase which activates immune system T cells, to some extent in the absence of calmodulin.
1. Tokheim, A.M., et al. 2006. Bioorg. Chem. 34: 66-76. PMID: 16464485
Soluble in ethanol (~100 mg/ml), DMSO (~100 mg/ml), and DMF (~100 mg/ml). Insoluble in water.
Store at -20° C
198° C at 0.08 mmHg
20 D 1.48
binding of [3H]-LTB4 to neutrophil membranes: K
i= 3 µM (pig)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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PMID: # 9108053 Cui, X.L. et al. 1997. Arachidonic acid activates c-jun N-terminal kinase through NADPH oxidase in rabbit proximal tubular epithelial cells. Proc. Natl. Acad. Sci. USA. 94: 3771-3776.
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Tokheim, AM. et al. (PubMed 16464485) reported that Eicosa-11Z,14Z-dienoic Acid effectively inhibited calcineurin. -SCBT Publication Review
Date published: 2015-06-02
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