EDTA, Disodium Salt, Dihydrate A chelating agent for metal ions; minimizes metal ion impurities in reaction buffers

EDTA, Disodium Salt, Dihydrate (CAS 6381-92-6)

EDTA, Disodium Salt, Dihydrate | CAS 6381-92-6 is rated 5.0 out of 5 by 1.
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Synonym: Disodium ethylenediaminetetraacetatedihydrate;Edetatedisodium saltdihydrate
Application: A chelating agent for metal ions; minimizes metal ion impurities in reaction buffers
CAS Number: 6381-92-6
Purity: ≥99%
Molecular Weight: 372.2
Molecular Formula: C10H14N2Na2O82H2O
* Refer to Certificate of Analysis for lot specific data (including water content).
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EDTA, Disodium Salt, Dihydrate is an extensively used chelator of divalent cations such as Ca2+. EDTA (Ethylenediaminetetraacetic acid) is a chelating agent, a general chemical, and a sequestrant. In molecular biology applications, it is used to minimize metal ion contaminants. Also used to facilitate enzymatic reactions that could be inhibited by heavy metal traces. Inhibits enzymes, such as metalloproteases, that require divalent cations for activity.


References

1. Van Kley, H. and Claywell, C.S. 1973. Clin. Chem. 19: 621-623. PMID: 4196140

Appearance :
Crystalline
Physical State :
Solid
Solubility :
Soluble in water (100 g/l) at 20 °C, and 3 M NaOH (100 mg/ml).
Storage :
Store at room temperature
Melting Point :
250° C (lit.)(dec.)
Boiling Point :
>100° C
Density :
1.01 g/cm3 at 25° C
Refractive Index :
n20D 1.36
pK Values :
pKa: 2.0, 2.7, 6.2, 10.3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
2
RTECS :
AH4375000
PubChem CID :
44120005
Merck Index :
14: 3517
MDL Number :
MFCD00150037
EC Number :
205-358-3
Beilstein Registry :
3900609
SMILES :
C(CN(CC(=O)[O-])CC(=O)[O-])N(CC(=O)O)CC(=O)O.O.O.[Na+].[Na+]

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Certificate of Analysis

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EDTA, Disodium Salt, Dihydrate  Product Citations

See how others have used EDTA, Disodium Salt, Dihydrate. Click on the entry to view the PubMed entry .

Citations 1 to 10 of 11 total

PMID: # 26211618  Wan, G. et al. 2015. Scientific reports. 5: 12527.

PMID: # 19623194  Li, D. et al. 2009. J. Cereb. Blood Flow Metab. epub.

PMID: # 19805344  Sharma, H. et al. 2009. Proc. Natl. Acad. Sci. U.S.A. 106: 16604-16609.

PMID: # 11839804  Kim, B.C. et al. 2002. Mol. Cell. Biol. 22(5): 1369-78.

PMID: # 11325813  Cusack, JC. et al. 2001. Cancer Res. 61: 3535-3540.

PMID: # 11306489  Hideshima, T. et al. 2001. Cancer Res. 61: 3071-3076.

PMID: # 10623846  Cario, E. et al. 2000. J. Immunol. 164: 966-972.

PMID: # 10801895  Wakino, S et al. 2000. JBC. 275: 22435-22441.

PMID: # 10535943  Hsu, HL. et al. 1999. Proc. Natl. Acad. Sci. U.S.A. 96: 12454-12458.

PMID: # 9660836  Favata, MF. et al. 1998. J. Biol. Chem. 273: 18623-18632.

Citations 1 to 10 of 11 total
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Rated 5 out of 5 by from Various publications cite EDTA as a chelator Various publications cite EDTA as a chelator of divalent cations, that is highly useful in molecular biology applications to minimize metal ion contaminants. -SCBT Publication Review
Date published: 2015-03-03
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