Dynamin Inhibitor II A Dynamin I inhibitor

Dynamin Inhibitor II (CAS 1119-97-7)

Dynamin Inhibitor II | CAS 1119-97-7 is rated 5.0 out of 5 by 1.
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Synonym: Myristyltrimethylammonium bromide
Application: A Dynamin I inhibitor
CAS Number: 1119-97-7
Molecular Weight: 336.4
Molecular Formula: C17H38NBr
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* Refer to Certificate of Analysis for lot specific data (including water content).
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Dynamin Inhibitor II is a cell-permeable cationic surfactant that reversibly inhibits Dynamin I GTPase activity (IC50 = 3.15 μM) by targeting the PH domain and interfering with phospholipid binding. Dynamin Inhibitor II has been shown to block Dynamin I-dependent SVE (synaptic vesicle endocytosis) in rat brain synaptosomes and Dynamin II-dependent RME (receptor-mediated endocytosis) in non-neuronal HeLa, A431, and COS-7 cells. Inhibition is competitive with respect to PS and noncompetitive with respect to GTP. Dynamin Inhibitor II is an inhibitor of Dynamin II.


References

1. Quan, A., et al. 2007. Mol. Pharmacol. 72:1425. 2. Hill, T.A., et al. 2004. Bioorg. Med. Chem. Lett. 14: 3275.

Physical State :
Solid
Solubility :
Soluble in water (10% (w/v)), ethanol, DMSO (10 mg/ml), and methanol.
Storage :
Store at room temperature
Melting Point :
245-250° C (lit.)
IC50 :
Dynamin-1: IC50 = 5.79 µM (human); Plasmodium falciparum: IC50 = 0.9 µM; Dynamin I GTPase: IC50 = 3.1 µM; Dynamin II GTPase: IC50 = 8.4 µM; Receptor-mediated: IC50 = 19.9 µM; Synaptic vesicle endocytosis : IC50 = 2.2 µM
Ki Data :
GTPase activity of dynamin I: Ki= 940 nM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
BS5776000
Transport :
UN 3261, Class 8, Packing group III
PubChem CID :
14250
Merck Index :
14: 6336
MDL Number :
MFCD00011770
EC Number :
214-291-9
Beilstein Registry :
3633227
SMILES :
CCCCCCCCCCCCCC[N+](C)(C)C.[Br-]

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Certificate of Analysis

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Rated 5 out of 5 by from Dynamin Inhibitor II was reported as a reversible Dynamin Inhibitor II was reported as a reversible inhibitor of Dynamin I GTPase activity by interfering with phospholipid binding, in many articles. -SCBT Publication Review
Date published: 2015-05-31
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