Duramycin A chloride secretion enhancer in airway epithelium

Duramycin (CAS 1391-36-2)

Duramycin | CAS 1391-36-2 is rated 5.0 out of 5 by 1.
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Synonym: Leucopeptin
Application: A chloride secretion enhancer in airway epithelium
CAS Number: 1391-36-2
Purity: ≥90%
Molecular Weight: 2013.27
Molecular Formula: C89H125N23O25S3
* Refer to Certificate of Analysis for lot specific data (including water content).
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Duramycin is a polypeptide antibiotic that enhances chloride secretion in airway epithelium. It is used in studies of cystic fibrosis.


References

1. Cloutier, M M., et al., 1990. Duramycin enhances chloride secretion in airway epithelium. The American journal of physiology. 259(3 Pt 1): C450-4. PMID: 2169195
2. Nakamura, S., et al., 1984. Inhibitory effect of duramycin on partial reactions catalyzed by (Na+,K+)-adenosinetriphosphatase from dog kidney. Biochemistry. 23(2): 385-9. PMID: 6320868

Physical State :
Solid
Derived From :
Streptoverticillium cinnamoneus
Storage :
Store at 4° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
BV7100000
MDL Number :
MFCD00133301

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Certificate of Analysis

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Duramycin  Product Citations

See how others have used Duramycin. Click on the entry to view the PubMed entry .

Citations 1 to 2 of 2 total

PMID: # 24514900  Curto, MÁ. et al. 2014. Genetics. 196: 1059-76.

PMID: # 22791719  Puts, CF. et al. 2012. J. Biol. Chem. 287: 30529-40.

Citations 1 to 2 of 2 total

In which type of solvents duramycin will not dissolve. Information needed for selective purification of duramycin from conjugates used such as DOTAGA

Asked by: Gurvinder
We have limited solubility information on this chemical. Duramycin is soluble in 0.1 M HCl at 10 mg/mL.
Answered by: Technical Support
Date published: 2019-01-06

What is the diluent used for duramycin? 

Asked by: YOKEFUN
Thank you for your question. We offer Duramycin (CAS 1391-36-2): sc-239840 as a solid and not in a solution. This is soluble in 0.1 M HCl at 10 mg/mL.
Answered by: Technical Support
Date published: 2018-01-30
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Rated 5 out of 5 by from Hou S; et al Hou S; et al. (PubMed ID: 26224023) determined that Duramycin bound to the c-terminus of GFP protein still specifically binds to Phosphatidylethanolamine, but has less toxcity than that of native Duramycin. -SCBT Publication Review
Date published: 2015-03-19
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