DuP-697A thiophene that inhibits Cox-2

DuP-697 (CAS 88149-94-4)

DuP-697 | CAS 88149-94-4 is rated 5.0 out of 5 by 1.
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Synonym: 5-bromo-2-(4-fluorophenyl)-3-(4-(methylsulfonyl)phenyl)-thiophene
Application: A thiophene that inhibits Cox-2
CAS Number: 88149-94-4
Purity: ≥98%
Molecular Weight: 411.3
Molecular Formula: C17H12BrFO2S2
* Refer to Certificate of Analysis for lot specific data (including water content).
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DuP-697, an anti-inflammatory agent, is an inhibitor of Cox-1 and Cox-2 with 50 fold more selectivity for Cox-2 (IC50 of 10 nM) than for Cox-1 (IC50 of 800 nM). DuP-697 has also demonstrated the ability to reduce the exaggerated release of prostaglandin (PG) E2 elicited by Bradykinin in hydronephrotic kidney cells. Mechanistic studies suggest that DuP-697 interacts reversibly with PG H Synthase-1 while irreversibly inhibiting PGHS-2. Further research shows that DuP-697 suppresses cell growth and induces apoptosis by cell-cycle arrest and caspase-8 activation.


References

1. Joshi, A.S., et al. 1994. J. Chromatogr. B, Biomed. Appl. 660: 143-150. PMID: 7858707
2. Seibert, K., et al. 1996. Br. J. Pharmacol. 117: 1016-1020. PMID: 8882591
3. Rosenstock, M., et al. 1999. Biochim. Biophys. Acta. 1440: 127-137. PMID: 10477832
4. Peng, H.L., et al. 2008. Ann. Hematol. 87: 121-129. PMID: 17999062

Physical State :
Solid
Solubility :
Soluble in DMSO (10 mg/mL), ethanol (5 mg/mL), DMF (~54 mg/mL), and 1:1 DMF: PBS (pH 7.2) (~0.5 mg/mL).
Storage :
Store at room temperature
Melting Point :
217.51° C
Boiling Point :
454.08° C at 760 mmHg
Density :
1.51 g/cm3
Refractive Index :
n20D 1.62
IC50 :
COX-2 : IC50 = 10 nM; COX-1: IC50 = 800 nM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
RTECS :
XM7870000
PubChem CID :
3177
SMILES :
CS(=O)(=O)C1=CC=C(C=C1)C2=C(SC(=C2)Br)C3=CC=C(C=C3)F

Download SDS (MSDS)

Certificate of Analysis

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Rated 5 out of 5 by from This compound was successfully used to inhibit This compound was successfully used to inhibit the expression of Cox-2. This is demonstrated by WB, a decrease in signal is observed for Cox-2 in A549 cells. -SCBT QC
Date published: 2015-04-03
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