Doxorubicin hydrochloride A Topo II inhibitor, DNA intercalator and powerful cytotoxic agent

Doxorubicin hydrochloride (CAS 25316-40-9)

Doxorubicin hydrochloride | CAS 25316-40-9 is rated 5.0 out of 5 by 1.
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Synonym: Adriamycin
Application: A Topo II inhibitor, DNA intercalator and powerful cytotoxic agent
CAS Number: 25316-40-9
Purity: ≥99%
Molecular Weight: 580.0
Molecular Formula: C27H29NO11•HCl
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

Doxorubicin hydrochloride is a DNA intercalator and powerful cytotoxic agent. Once it associates with the DNA groove, a covalent linkage forms between a DNA base and the pendant sugar of the small molecule. The intercalation into DNA blocks the replication of DNA by blocking Topo II (Topoisomerase II). This general mechanism gives it efficacy in a wide range of different cell types. Additionally, the expression of the oncogenes c-Myc and c-Jun is also down regulated by the chemical and a significant correlation was reported between the level of expression of these genes and the degree of cell growth inhibition conferred by Doxorubicin. Doxorubicin hydrochloride is an inhibitor of AMPK, TERT and POLR.


References

1. Taatjes, D.J., et al. 1996. J. Med. Chem. 39: 4135-4138. PMID: 8863788

2. Pourquier, P., et al. 1998. Biochem. Pharmacol. 55: 1963-1971. PMID: 9714316

3. Zeman, S.M., et al. 1998. Proc. Natl. Acad. Sci. U. S. A. 95: 11561-11565. PMID: 9751705

Usage :
Stable for up to 1 year after receipt when stored at -20°C. Stock solutions should be aliquoted and stored at -20°C for up to 1 month.
Physical State :
Solid
Solubility :
Soluble in water (50 mM), methanol, isotonic sodium chloride, and DMSO (>10 mg/ml). Insoluble in chloroform, and ether.
Storage :
Store at room temperature
Melting Point :
216° C (dec.)
Fluoresence :
λex 470 nm, λem 585 nm in ethanol
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
QI9295900
PubChem CID :
443939
Merck Index :
14: 3439
MDL Number :
MFCD00077757
EC Number :
246-818-3
Beilstein Registry :
4229251
SMILES :
C[C@H]1[C@H]([C@H](C[C@@H](O1)O[C@H]2C[C@@](CC3=C(C4=C(C(=C23)O)C(=O)C5=C(C4=O)C=CC=C5OC)O)(C(=O)CO)O)N)O.Cl

Download SDS (MSDS)

Certificate of Analysis

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Doxorubicin hydrochloride  Product Citations

See how others have used Doxorubicin hydrochloride. Click on the entry to view the PubMed entry .

Citations 1 to 10 of 11 total

PMID: # 27929731  Sharif, T. et al. 2016. Autophagy. 1-21.

PMID: # 27814544  Isidori, M. et al. 2016. Environ. Pollut. 219: 275-287.

PMID: # 26971211  Ferre-Aracil, J. et al. 2016. The Science of the total environment. 556: 70-9.

PMID: # 26616471  Polak, R. et al. 2015. Advanced healthcare materials. 4: 2832-41.

PMID: # 26114658  Zhou, J. et al. 2015. Autophagy. 11: 1259-79.

PMID: # 25124055  Negreira, N. et al. 2014. Sci. Total Environ. 497-498: 68-77.

PMID: # 24667756  Negreira, N. et al. 2014. The Science of the total environment. 482-483: 389-98.

PMID: # 24148406  2013. Talanta. 116: 290-9.

PMID: # 23357749  Negreira, N. et al. 2013. J Chromatogr A. 1280: 64-74.

PMID: # 22427918  Chen S et al. 2012. PLoS One. 7: e32971.

Citations 1 to 10 of 11 total

How should I store this after resuspension? Is it ok to store it at -80° C?

Asked by: SCM4
Doxorubicin hydrochloride is stable for up to 1 month at -20℃ and up to 6 months at -80℃ when resuspended in DMSO. Whenever possible, however, solutions should be made and used the same day.
Answered by: Tech Service 11
Date published: 2017-03-02
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Rated 5 out of 5 by from An increase in p21 protein expression by An increase in p21 protein expression by HCT116 cells was observed by WB after treatment with doxorubicin hydrochloride (sc-200923). -SCBT QC
Date published: 2015-03-31
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