Doxorubicin hydrochloride is a DNA intercalator and powerful cytotoxic agent. Once it associates with the DNA groove, a covalent linkage forms between a DNA base and the pendant sugar of the small molecule. The intercalation into DNA blocks the replication of DNA by blocking Topo II (Topoisomerase II). This general mechanism gives it efficacy in a wide range of different cell types. Additionally, the expression of the oncogenes c-Myc and c-Jun is also down regulated by the chemical and a significant correlation was reported between the level of expression of these genes and the degree of cell growth inhibition conferred by Doxorubicin. Doxorubicin hydrochloride is an inhibitor of AMPK, TERT and POLR.
1. Taatjes, D.J., et al. 1996. J. Med. Chem. 39: 4135-4138. PMID: 8863788
2. Pourquier, P., et al. 1998. Biochem. Pharmacol. 55: 1963-1971. PMID: 9714316
3. Zeman, S.M., et al. 1998. Proc. Natl. Acad. Sci. U. S. A. 95: 11561-11565. PMID: 9751705
See how others have used Doxorubicin hydrochloride. Click on the entry to view the PubMed entry .
PMID: # 27929731 Sharif, T. et al. 2016. Autophagy. 1-21.
PMID: # 27814544 Isidori, M. et al. 2016. Environ. Pollut. 219: 275-287.
PMID: # 26971211 Ferre-Aracil, J. et al. 2016. The Science of the total environment. 556: 70-9.
PMID: # 26616471 Polak, R. et al. 2015. Advanced healthcare materials. 4: 2832-41.
PMID: # 26114658 Zhou, J. et al. 2015. Autophagy. 11: 1259-79.
PMID: # 25124055 Negreira, N. et al. 2014. Sci. Total Environ. 497-498: 68-77.
PMID: # 24667756 Negreira, N. et al. 2014. The Science of the total environment. 482-483: 389-98.
PMID: # 24148406 2013. Talanta. 116: 290-9.
PMID: # 23357749 Negreira, N. et al. 2013. J Chromatogr A. 1280: 64-74.
PMID: # 22427918 Chen S et al. 2012. PLoS One. 7: e32971.
Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2019 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.