Doxorubicin An immunosuppresive antineoplastic antibiotic

Doxorubicin (CAS 23214-92-8)

Doxorubicin | CAS 23214-92-8 is rated 5.0 out of 5 by 3.
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Synonym: Adriamycin
Application: An immunosuppresive antineoplastic antibiotic
CAS Number: 23214-92-8
Purity: ≥99%
Molecular Weight: 543.52
Molecular Formula: C27H29NO11
* Refer to Certificate of Analysis for lot specific data (including water content).
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Doxorubicin is an antineoplastic antibiotic isolated from Streptomyces peucetius var. caesius. The apparent mechanism involves the formation of a stable complex with DNA, interfering with the synthesis of nucleic acids. Doxorubicin also possesses immunosuppressant properties. Doxorubicin is an inhibitor of Topo II.

Physical State :
Solid
Derived From :
Streptomyces peucetius
Solubility :
Soluble in water (partly), and alcohols.
Storage :
Store at room temperature
Boiling Point :
~810.3° C at 760 (Predicted)
Density :
~1.6 g/cm3 (Predicted)
Refractive Index :
n20D 1.71 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
31703
MDL Number :
MFCD00869292
SMILES :
C[C@H]1[C@H]([C@H](C[C@@H](O1)O[C@H]2C[C@@](CC3=C(C4=C(C(=C23)O)C(=O)C5=C(C4=O)C=CC=C5OC)O)(C(=O)CO)O)N)O

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Certificate of Analysis

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Doxorubicin  Product Citations

See how others have used Doxorubicin. Click on the entry to view the PubMed entry .

Citations 1 to 10 of 13 total

PMID: # 28851536  Heider, T. et al. 2017. Biochim. Biophys. Acta. 1860: 1127-1137.

PMID: # 28608259  Qiu, M. et al. 2017. Cancer Chemother. Pharmacol. 80: 275-286.

PMID: # 28427150  Studencka, M. et al. 2017. Oncotarget. 8: 30656-30671.

PMID: # 27239736  Stoskus, M. et al. 2016. Leukemia research. 47: 16-21.

PMID: # 26873573  Chwee, JY. et al. 2016. Cancer immunology research. 4: 294-302.

PMID: # 27754745  Kim, M. et al. 2016. Autophagy. 1-20.

PMID: # 25837271  2015. Phytomedicine. 22: 344-51.

PMID: # 25691007  Fantappiè, O. et al. 2015. Journal of cellular and molecular medicine. 19: 1410-7.

PMID: # 25747987  Wang, Z. et al. 2015. Biol. Pharm. Bull. 38: 277-84.

PMID: # 25915824  Jeong, D. et al. 2015. Leukemia. 29: 1868-74.

Citations 1 to 10 of 13 total

How long is a doxorubicin solution (in water) stable at 4°C? Unfortunately it precipitates as soon as I dilute it in Cell Culture Media. Do you have an advice for how to avoid such problem?

Asked by: JC92
Highly concentrated solutions of doxorubicin are prone to precipitation, which is why they are best prepared within 12-24 hours before they are used in a given experiment. Due to the solubility of doxorubicin being 10x higher in DMSO than in water, you might consider switching to this solvent instead.
Answered by: SCBT Heidelberg Support
Date published: 2018-12-30

Density?

Asked by: mar90
Thank you for your question. The predicted density value for this product is 1.6g/cm3. If you have any further questions, please contact our European Technical Service team. You can reach them by phone at Toll Free: +49 6221 4503 0, by email at: europe@scbt.com or by live chat directly on our website, www.scbt.com
Answered by: Tech Service
Date published: 2017-06-06
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Rated 5 out of 5 by from A VERY GOOD PRODUCT PMID 25837271 USED THIS PRODUCT. IT IS A VERY GOOD PRODUCT.
Date published: 2017-05-23
Rated 5 out of 5 by from A VERY GOOD PRODUCT I USED IT IN MY MANUSCRIPT. IT IS A VERY GOOD PRODUCT.
Date published: 2017-04-04
Rated 5 out of 5 by from Varga et al Varga et al. (PubMed ID 26386112) used doxorubicin to induce mitochondrial-related cytotoxicity. -SCBT Publication Review
Date published: 2015-05-01
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