Dorzolamide HydrochlorideAn inhibitor of carbonic anhydrase

Dorzolamide Hydrochloride (CAS 130693-82-2)

Dorzolamide Hydrochloride | CAS 130693-82-2 is rated 5.0 out of 5 by 1.
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Application: An inhibitor of carbonic anhydrase
CAS Number: 130693-82-2
Purity: ≥98%
Molecular Weight: 360.90
Molecular Formula: C10H17ClN2O4S3
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

Dorzolamide Hydrochloride is an inhibitor of carbonic anhydrase. Dorzolamide Hydrochloride is an inhibitor of CA II, CA IX, CA V, CA VI, CA XII, CA XIII and CA XIV.


References

Lippa, E.A., et al.: Ophthalmology, 98, 308 (1991), Wang, R.-F., et al.: Arch. Ophthalmol., 109, 1297 (1991), Whikehart, D., et al.: J. Ocul. Pharmacol., 7, 195 (1991), Sjoquist, B., et al.: Drug Metab. Dispos., 26, 745 (1998),

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in water (14 mg/ml at 25° C), methanol, DMSO (<1 mg/ml at 25° C), ethanol (sparingly), and DMF (sparingly).
Storage :
Store at 4° C
Melting Point :
>247° C (dec.)
Refractive Index :
n20D ~1.63 (Predicted)
Optical Activity :
α20/D -8°±1°, c = 1 in methanol
IC50 :
CA II: IC50 = 0.18 nM (human); Carbonic anhydrase IV: IC50 = 43 nM (bovine); CA IX: IC50 = 52 nM (human)
Ki Data :
CA II: Ki= 0.28 nM (human); CA XII: Ki= 3.5 nM (human); CA VII: Ki= 3.5 nM (human); CA VI: Ki= 10 nM (human); CA XIII: Ki= 18 nM (human)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
XJ9095163
PubChem CID :
6918132
Merck Index :
14: 3426
MDL Number :
MFCD00884659
Beilstein Registry :
5896026
SMILES :
CCN[C@H]1C[C@@H](S(=O)(=O)C2=C1C=C(S2)S(=O)(=O)N)C.Cl

Download SDS (MSDS)

Certificate of Analysis

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Rated 5 out of 5 by from Moschos MM; et al Moschos MM; et al. (PubMed ID: 26270771) determined Dorzolamide Hydrochloride, an anti-glaucoma eye drop solution, to inhibit PAF the least. However, PAF inhibition effectiveness may be correlated with drop efficacy. -SCBT Publication Review
Date published: 2015-05-12
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