Dorsomorphin dihydrochloride A potent and selective AMPK inhibitor

Dorsomorphin dihydrochloride (CAS 1219168-18-9)

Dorsomorphin dihydrochloride | CAS 1219168-18-9 is rated 5.0 out of 5 by 2.
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Synonym: 6-[4-[2-(1-PIPERIDINYL)ETHOXY]PHENYL]-3-(4-PYRIDINYL)-PYRAZOLO[1,5-A]PYRIMIDINE DIHYDROCHLORIDE
Application: A potent and selective AMPK inhibitor
CAS Number: 1219168-18-9
Purity: ≥97%
Molecular Weight: 472.41
Molecular Formula: C24H25N5O•2HCl
* Refer to Certificate of Analysis for lot specific data (including water content).
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Dorsomorphin dihydrochloride has been shown to act as a potent and selective inhibitor of AMP-activated protein kinase (AMPK; Ki = 109 nM), induced by AICAR and metformin. Dorsomorphin dihydrochloride also inhibits the bone morphogenetic protein type 1 receptors ACTR-I (ALK2), BMPR-IA (ALK3), and BMPR-IB (ALK 6). This compound is not thought to show significant activity on structurally related kinases. Dorsomorphin, Free Base, is also available (sc-200689).

Physical State :
Solid
Solubility :
Soluble in water (100 mM), and DMSO (20 mM).
Storage :
Desiccate at room temperature
Refractive Index :
n20D 1.67 (Predicted)
IC50 :
c-Src: IC50 = 2 nM (human); Flk-1: IC50 = 4 nM (human); EphA2: IC50 = 11 nM (human); Mnk1: IC50 = 11 nM (human); Flt-1: IC50 = 11 nM (human)
Ki Data :
AMP-activated protein kinase: Ki= 109 nM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
49761481
MDL Number :
MFCD11112197
SMILES :
C1CCN(CC1)CCOC2=CC=C(C=C2)C3=CN4C(=C(C=N4)C5=CC=NC=C5)N=C3.Cl.Cl

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Certificate of Analysis

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Dorsomorphin dihydrochloride  Product Citations

See how others have used Dorsomorphin dihydrochloride. Click on the entry to view the PubMed entry .

Citations 1 to 4 of 4 total

PMID: # 26626025  Shimojo, D. et al. 2015. Molecular brain. 8: 79.

PMID: # 25944759  Choi, HS. et al. 2015. Molecular nutrition & food research. 59: 1458-71.

PMID: # 26176666  Zou, D. et al. 2015. PloS one. 10: e0133336.

PMID: # 26247736  Su, X. et al. 2015. Cell death & disease. 6: e1851.

Citations 1 to 4 of 4 total

What is the solubility of this product?

Asked by: hawkeye11
Thank you for your question. Dorsomorphin dihydrochloride: sc-361173 is soluble to 100 mM in water and to 20 mM in DMSO, stable.
Answered by: Technical Support
Date published: 2019-03-19
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Rated 5 out of 5 by from Works reliably I used it in dual SMAD inhibition protocol for for neuronal differentiation of human PSCs over past several years.
Date published: 2017-05-09
Rated 5 out of 5 by from Noisa Noisa, P. et al. (PubMed 26064138) used Dorsomorphin dihydrochloride, a potent and selective inhibitor of AMP-activated protein kinase, to induce human embryonic stem cells to neural progenitor cells. -SCBT Publication Review
Date published: 2015-04-29
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