Dorsomorphin dihydrochloride has been shown to act as a potent and selective inhibitor of AMP-activated protein kinase (AMPK; Ki = 109 nM), induced by AICAR and metformin. Dorsomorphin dihydrochloride also inhibits the bone morphogenetic protein type 1 receptors ACTR-I (ALK2), BMPR-IA (ALK3), and BMPR-IB (ALK 6). This compound is not thought to show significant activity on structurally related kinases. Dorsomorphin, Free Base, is also available (sc-200689).
Rated 5 out of
Works reliablyI used it in dual SMAD inhibition protocol for for neuronal differentiation of human PSCs over past several years.
Date published: 2017-05-09
Rated 5 out of
NoisaNoisa, P. et al. (PubMed 26064138) used Dorsomorphin dihydrochloride, a potent and selective inhibitor of AMP-activated protein kinase, to induce human embryonic stem cells to neural progenitor cells. -SCBT Publication Review
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