DMSA (Meso-2,3-dimercaptosuccinic acid) A water-soluble chelating agent

DMSA (Meso-2,3-dimercaptosuccinic acid) (CAS 304-55-2)

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Application: A water-soluble chelating agent
CAS Number: 304-55-2
Purity: 97%
Molecular Weight: 182.22
Molecular Formula: C4H6O4S2
* Refer to Certificate of Analysis for lot specific data (including water content).
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DMSA (Meso-2,3-dimercaptosuccinic acid) is a potent lead chelating agent found to be a scavenger of reactive oxygen species (ROS). Murine experiments have shown that this compound also lowers blood pressure in rat arterial hypertension via a decrease in total cell calcium levels. It has also been observed that DMSA upregulates mRNA expression of macrophage-1 antigen, L-, E-, and P-selectin, as well as causing an increase in TNFα (tumor necrosis factor-α) concentrations in murine lung. Mechanistic studies suggest that DMSA is metabolized into mixed disulfides of cysteine, which are active chelating agents.


References

1. Vineeta, N., et al. 2001. J Indian Soc Pedod Prev Dent. 19: 160-163. PMID: 12396095
2. Kramer, H.J., et al. 2003. Biochem. Pharmacol. 65: 1741-1746. PMID: 12754110
3. Bradberry, S., et al. 2009. Clin Toxicol. 47: 617-631. PMID: 19663612
4. Bradberry, S., et al. 2009. QJM. 102: 721-732. PMID: 19700440
5. Azevedo, R.B., et al. 2011. Cell Adh Migr. [Epub ahead of print]. PMID: 20935452

Physical State :
Solid
Solubility :
Soluble in water, and ethanol (25 mg/ml, Colorless to Light Yellow, Clear).
Storage :
Store at -20° C
Melting Point :
196-198° C (lit.)(dec.)
Boiling Point :
~267.6° C at 760 mmHg (Predicted)
Density :
1.62 g/cm3 (Predicted)
Refractive Index :
n20D 1.62 (Predicted)
Optical Activity :
α25/D 0°±1°, c = 1 in DMF
pK Values :
pKa: 2.74 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
2
RTECS :
WM7650000
PubChem CID :
2724354
Merck Index :
14: 8865
MDL Number :
MFCD00064799
EC Number :
206-155-2
Beilstein Registry :
1725150
SMILES :
OC(=O)C(S)C(S)C(O)=O

Download SDS (MSDS)

Certificate of Analysis

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