DMH-1

DMH-1 (CAS 1206711-16-1)

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Synonym: BMP Inhibitor II; 4-[6-[4-(1-Methylethoxy)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]-quinoline
Application: A selective inhibitor of the bone morphogenic protein (BMP) ALK2 receptor
CAS Number: 1206711-16-1
Molecular Weight: 380.44
Molecular Formula: C24H20N4O
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* Refer to Certificate of Analysis for lot specific data (including water content).
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DMH-1 is a selective inhibitor of ACTR-I, the bone morphogenic protein (BMP) ALK2 receptor. This compound has an IC50 = 108 nM and displayes no detectable inhibition of AMPK, ALK5, KDR (VEGFR-2) or PDGFRβ receptors. DMH-1 blocks phosphorylation of Smads 1, 5, and 8 in HEK293 cells induced by BMP4.

Physical State :
Solid
Solubility :
Soluble in DMSO (50 mM).
Storage :
Desiccate at 4° C
Density :
~1.2 g/cm3 (Predicted)
Refractive Index :
n20D 1.67 (Predicted)
IC50 :
ACTR-I: IC50 = 108 nM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
Transport :
UN 2811, Class 6.1, Packing group III
PubChem CID :
50997747
MDL Number :
MFCD18384963
SMILES :
CC(C)OC1=CC=C(C=C1)C2=CN3C(=C(C=N3)C4=CC=NC5=CC=CC=C45)N=C2

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DMH-1  Product Citations

See how others have used DMH-1. Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 26387793  Li, AS. et al. 2015. Mol. Reprod. Dev. 82: 1015-36.

Citations 1 to 1 of 1 total
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