DMH-1 is a selective inhibitor of ACTR-I, the bone morphogenic protein (BMP) ALK2 receptor. This compound has an IC50 = 108 nM and displayes no detectable inhibition of AMPK, ALK5, KDR (VEGFR-2) or PDGFRβ receptors. DMH-1 blocks phosphorylation of Smads 1, 5, and 8 in HEK293 cells induced by BMP4.
Soluble in DMSO (50 mM).
Desiccate at 4° C
~1.2 g/cm3 (Predicted)
n20D 1.67 (Predicted)
ACTR-I: IC50 = 108 nM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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