DL-Propargylglycine (hydrochloride) is an irreversible inhibitor of cystathionine-γ-lyase (CSE), which is a H2S synthesizing enzyme. Studies show that DL-Propargylglycine (hydrochloride) effects glycogenolysis in rat hepatocytes. This acetylenic amino acid can also inhibit alanine aminotransferase in hepatocytes and to a lesser extent inhibits aspartate aminotransferase. Alternate studies on Lemna paucicostata Hegelm show that DL-Propargylglycine (hydrochloride) inhibits methionine biosynthesis, causes growth inhibition, and morphological changes.
1. Datko, A.H. and Mudd, S.H. 1982. Plant Physiol. 69: 1070-1076. PMID: 16662347
2. Cornell, N.W., et al. 1984. Biochem. J. 220: 707-716. PMID: 6466297
3. Kawaji, A., et al. 1992. J. Pharmacobio-dyn. 15: 107-112. PMID: 1320679
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