DL-α-Difluoromethylornithine hydrochloride inhibits polyamine biosynthesis by selective, irreversible inhibition of ornithine decarboxylase (ODC). DMFO hydrochloride is a chemoprotective agent that blocks angiogenesis.
1. Takigawa, M., et al., 1990. Tumor angiogenesis and polyamines: alpha-difluoromethylornithine, an irreversible inhibitor of ornithine decarboxylase, inhibits B16 melanoma-induced angiogenesis in ovo and the proliferation of vascular endothelial cells in vitro. Cancer research. 50(13): 4131-8. PMID: 1693880
2. Jasnis, M A., et al., 1994. Polyamines prevent DFMO-mediated inhibition of angiogenesis. Cancer letters. 79(1): 39-43. PMID: 7514492
3. Takahashi, Y., et al., 2000. alpha-difluoromethylornithine induces apoptosis as well as anti-angiogenesis in the inhibition of tumor growth and metastasis in a human gastric cancer model. International journal of cancer. Journal international du cancer. 85(2): 243-7. PMID: 10629084
4. Sharma, S., et al., . A quantitative angiogenesis model for efficacy testing of chemopreventive agents. Anticancer research. 21(6A): 3829-37. PMID: 11911254
H2O: 10 mg/mL, soluble: DMSO: 2 mg/mL insoluble
Store at room temperature
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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TsaiTsai, YH. et al. (PubMed 26140984) reported that suppression of ornithine decarboxylase by DL- -Difluoromethylornithine hydrochloride promotes osteogenic differentiation of human bone marrow-derived mesenchymal stem cells. -SCBT Publication Review
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