DipyroneA non-steroidal antiinflammatory drug

Dipyrone (CAS 68-89-3)

Dipyrone | CAS 68-89-3 is rated 4.0 out of 5 by 1.
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Synonym: Sulpyrine; Methampyrone
Application: A non-steroidal antiinflammatory drug
CAS Number: 68-89-3
Purity: ≥98%
Molecular Weight: 333.34
Molecular Formula: C13H16N3O4S•Na
* Refer to Certificate of Analysis for lot specific data (including water content).
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Dipyrone is a non-steroidal antiinflammatory drug that, when coadministered with morphine, potentiates its antinociceptive action and delays the development of tolerance. Dipyrone is a selective inhibitor of cyclooxygenase-3 (COX-3), with lower activity against COX


References

1. Hernandez-Delgadillo, G.P., et al., Morphine and dipyrone co-administration delays tolerance development and potentiates antinociception. Eur. J. Pharmacol. 469, 71-79, (2003) 2. Parada, C.A., et al., Activation of presynaptic NMDA receptors coupled to NaV1.8-resistant sodium channel C-fibers causes retrograde mechanical nociceptor sensitization. Proc. Natl. Acad. Sci. U. S. A. 100, 2923-2928, (2003) 3. Chandrasekharan, N.V., et al., COX-3, a cyclooxygenase-1 variant inhibited by acetaminophen and other analgesic/antipyretic drugs: cloning, structure, and expression. Proc. Natl. Acad. Sci. U. S. A. 99, 13926-13931, (2002)

Physical State :
Solid
Storage :
Store at 4° C
Melting Point :
180° C
Boiling Point :
>374° C
Density :
~650 kg/m3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
522325
MDL Number :
MFCD00020783
EC Number :
200-694-7
SMILES :
CC1=C(C(=O)N(N1C)C2=CC=CC=C2)N(C)CS(=O)(=O)[O-].[Na+]

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Certificate of Analysis

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Dipyrone  Product Citations

See how others have used Dipyrone. Click on the entry to view the PubMed entry .

Citations 1 to 4 of 4 total

PMID: # 27479756  Kishimoto, TK. et al. 2016. Nat Nanotechnol. 11: 890-899.

PMID: # 25467825  Ertin, IH. et al. 2015. Acta Neuropsychiatr. 27: 48-52.

PMID: # 25647230  Gencer, A. et al. 2015. Drug Res (Stuttg). 65: 645-9.

PMID: # 23784345  Elmas, P. et al. 2013. J Neural Transm (Vienna). 120: 1533-8.

Citations 1 to 4 of 4 total

What is the difference between sc-252755A; sc-252755B and sc-252755C under "Dipyrone"? Just the quantity or other chemical properties? Another question: Is the molecule of Dipyrone sodium anhydrous or it includes one molecule of water?

Asked by: Ana Karina
Thank you for your question. The different letters after the product code only indicate the packing size of each unit. There are no differences in regard to chemical properties.
Answered by: Technical Support Europe
Date published: 2019-03-25

Can you please provide the solubility of this compound?

Asked by: two2igm05
Thank you for your question. The chemical with catalogue number sc-252755 is very soluble in water. If you have any further questions or concerns, please feel free to contact our Technical Service department by calling 800-457-3801 option 2, emailing scbt@scbt.com, or using the Live Chat function on our website.
Answered by: Tech Service 8
Date published: 2016-12-29
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Rated 4 out of 5 by from I will rate this product a 4 and rate 5 I will rate this product a 4 and rate 5 for your logistics, customer service and support.
Date published: 2015-04-20
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