Dimethylethylammoniumpropane sulfonate

Dimethylethylammoniumpropane sulfonate (CAS 160255-06-1)

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Synonym: NDSB 195
Application: A zwitterionic solubilizing agent with usefulness in protein crystallization
CAS Number: 160255-06-1
Molecular Weight: 195.28
Molecular Formula: C7H17NO3S
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Dimethylethylammoniumpropane sulfonate is a compound used for non-denaturing protein purification. It has been shown to increase the extraction yield of membrane, nuclear and cytoskeletal associated proteins. Zwitterionic over a wide pH range, easily removed by dialysis and no significant absorption in the near UV range. Specific applications include microsomal protein extraction, nuclear protein recovery, precipitation reduction in IEF, and membrane-bound protease purification. Dimethylethylammoniumpropane sulfonate has been used in a study to assess the functional properties of the separate subunits of the human DNA helicase II/Ku autoantigen. It has also been used in a study to investigate the swelling behaviors of copolymeric hydrogels in various saline solutions.


1. Vuillard, L., et al. 1995. Biochem. J. 305: 337-343. PMID: 782635

Appearance :
Physical State :
Solubility :
Soluble in water.
Storage :
Store at room temperature
Melting Point :
>300° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
Transport :
UN 3261, Class 8, Packing group III
MDL Number :

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