Dimethyl Sulfoxide (DMSO) A versatile highly polar organic solvent

Dimethyl Sulfoxide (DMSO) (CAS 67-68-5)

Dimethyl Sulfoxide (DMSO) | CAS 67-68-5 is rated 5.0 out of 5 by 6.
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Synonym: Methyl sulfoxide; Dimethyl sulphoxide; Methylsulfinylmethane
Application: A versatile highly polar organic solvent
CAS Number: 67-68-5
Purity: ≥99%
Molecular Weight: 78.13
Molecular Formula: C2H6OS
* Refer to Certificate of Analysis for lot specific data (including water content).
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Dimethyl Sulfoxide (DMSO) is a highly polar organic solvent with many applications in chemical and biological research. DMSO can uniquely provide solubility to certain very polar small molecules, such as simple biomolecules with multiple protic functional groups. It can also be used as an oxidation reagent in certain transformations. The yield of PCR processes is amplified with DMSO as a co-solvent, helping to inhibit the formation of secondary structures from DNA fragments. In addition, the solvent has reported uses in the prevention of ice crystal formation during cryopreservation. Ice crystal formation damages cells and tissues and normally results in their death. DMSO is an excellent option for cryopreservation because it is able to penetrate cells and tissues easily, preventing ice formation within the cell and it has low toxicity.
Also available: Dimethyl Sulfoxide (DMSO), cell culture reagent (sc-358801)


References

1. Sweat, F.W. and Epstein, W.W. 1967. J. Org. Chem. 32(3): 835-838. PMID: 6042131
2. Chakrabarti, R. and Schutt, C.E. 2001. Gene. 274(1-2): 293-298. PMID: 11675022
3. Pegg, D.E. 2007. Methods Mol. Biol. 368 : 39-57. PMID: 18080461

Usage :
To prepare a sterile filtered DMSO solution, it is recommended to use a teflon or nylon membrane. Cellulose acetate membranes are not recommended
Physical State :
Liquid
Solubility :
Soluble in water, ethanol, ether, benzene, chloroform, and acetone.
Storage :
Store at room temperature
Melting Point :
16-19° C
Boiling Point :
189° C
Density :
1.10 g/mL
Refractive Index :
n20D 1.48 (lit.)
IC50 :
HII4E cells : IC50 = 199 µg/ml (mouse)
Ki Data :
Choline acetylase: Ki= 25000000 nM (Rattus norvegicus)
pK Values :
pKa: -4.54
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
1
RTECS :
PV6210000
PubChem CID :
679
Merck Index :
14: 3259
MDL Number :
MFCD00002089
EC Number :
200-664-3
Beilstein Registry :
506008
SMILES :
CS(=O)C

Download SDS (MSDS)

Certificate of Analysis

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Dimethyl Sulfoxide (DMSO)  Product Citations

See how others have used Dimethyl Sulfoxide (DMSO). Click on the entry to view the PubMed entry .

Citations 1 to 10 of 13 total

PMID: # 28443590  Soyman, Z. et al. 2017. Balkan Med J. 34: 444-449.

PMID: # 28752496  Ding, M. et al. 2017. Cytotechnology.

PMID: # 28693141  Lee, JS. et al. 2017. Oncol Lett. 14: 103-110.

PMID: # 27483253  Librizzi, M. et al. 2016. Int J Mol Sci. 17:

PMID: # 26895409  Mizokami, SS. et al. 2016. PLoS ONE. 11: e0149656.

PMID: # 27420076  Lee, D. et al. 2016. Int J Environ Res Public Health. 13:

PMID: # 26593928  Lee, D. et al. 2015. Int J Environ Res Public Health. 12: 14610-25.

PMID: # 25617481  Pinho-Ribeiro, FA. et al. 2015. Chem. Biol. Interact. 228: 88-99.

PMID: # 24954315  Baek, SJ. et al. 2014. Yonsei Med. J. 55: 886-94.

PMID: # 24375454  2014. Eur. J. Immunol. 44: 1108-18.

Citations 1 to 10 of 13 total

Dear Sir/ Madam, A customer of ours needs 50 x 5ml/vial of DMSO. Please kindly quote if you could provide us with such a pack

Asked by: Hsing
Thank you for your question. Please call our Asian Support office toll-free at 800-820-8626, email asia@scbio.cn, or contact us by live chat.
Answered by: Technical Support
Date published: 2018-01-31

Is this chemical usable for food?

Asked by: sg1020v
Thank you for your question. No, our chemicals are intended for research use only. They are not recommended for diagnostic or therapeutic use, and they are definitely not intended for use in consumable goods such as food.
Answered by: Technical Support
Date published: 2017-11-02

Can you offer it in medical grade?

Asked by: chemsd02
Thank you for your question. sc-202581 (Dimethyl Sulfoxide (DMSO), CAS 67-68-5) cannot be offered in medical grade.
Answered by: Chemical Support 10
Date published: 2017-04-06

Is the ChemCruz Dimethyl Sulfoxide (DMSO) sc-202581 sterile? 

Asked by: SCM4
This chemical, DMSO, is not considered sterile.
Answered by: Chemical Support 1
Date published: 2017-03-09

Is this product ACS grade?

Asked by: hawkeye11
This chemical, Dimethyl Sulfoxide (CAS 67-68-5), is ACS grade.
Answered by: Chemical Support 1
Date published: 2017-03-09
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Rated 5 out of 5 by from great We use this product effect is very good, the solvent is very easy to use, can provide high quality results!
Date published: 2017-02-07
Rated 5 out of 5 by from Good! This highly polar organic solvent being used in many chemical and biological research can uniquely provide solubility to certain very polar small molecules with a high quality.
Date published: 2017-01-22
Rated 5 out of 5 by from good The solvent is very easy to use! I used it and had good experimental results! My partner and I are satisfied with it!
Date published: 2016-11-19
Rated 5 out of 5 by from Works fine We used to use this product and very much satisfied with the quality.
Date published: 2016-11-01
Rated 5 out of 5 by from We use it in the lab and it works fine We use it in the lab and it works fine.
Date published: 2015-09-22
Rated 5 out of 5 by from Use this routinely in our lab and has good quality Use this routinely in our lab and has good quality.
Date published: 2015-09-02
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