Dihomo-gamma-linolenylethanolamideA CB1 and CB2 agonist and adenylyl cyclase inhibitor

Dihomo-γ-linolenylethanolamide (CAS 150314-34-4)

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Application: A CB1 and CB2 agonist and adenylyl cyclase inhibitor
CAS Number: 150314-34-4
Molecular Weight: 349.6
Molecular Formula: C22H39NO2
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Dihomo-γ-linolenylethanolamide is an endocannabinoid. Binds to recombinant human CB1 (Ki = 857 nM) and CB2 receptor (Ki = 598nM). Also inhibits adenylyl cyclase (IC50 =109 nM).


References

1. Hanus, L., et al. 1993. J. Med. Chem. 36: 3032-3034. PMID: 8411021
2. Barg, J., et al. 1995. Eur. J. Pharmacol. 287: 145-152. PMID: 8749028
3. Felder, C.C., et al. 1993. Proc. Natl. Acad. Sci. U.S.A. 90: 7656-7660. PMID: 8395053
4. Felder, C.C., et al. 1995. Mol. Pharmacol. 48: 443-450. PMID: 7565624
5. Walter, L., et al. 2002. Biol. Chem. 277: 20869-20876. PMID: 11916961

Formulation :
Solution in ethanol
Physical State :
Liquid
Solubility :
Soluble in DMSO (30mg/ml) or dimethyl formamide (10mg/ml); 8mg/ml soluble in a 1:2 solution of ethanol:PBS (pH 7.2) (dilute the ethanol solution with PBS).
Storage :
Store at -20° C
Boiling Point :
~508.04° C (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
5282272
SMILES :
CCCCCC=CCC=CCC=CCCCCCCC(=O)NCCO

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Certificate of Analysis

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