Digitonin

Digitonin (CAS 11024-24-1)

Digitonin | CAS 11024-24-1 is rated 5.0 out of 5 by 1.
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Synonym: Digitin
Application: A non-ionic biodetergent used to solubilize membrane-bound proteins
CAS Number: 11024-24-1
Molecular Weight: 1229.31
Molecular Formula: C56H92O29
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Digitonin is a non-ionic detergent commonly used to solubilize membrane-bound proteins.

Usage :
Protect from moisture.

Reconstitute at 1 g/20 ml in boiling H2O. Heat for 15 min at 98°C. Cool and place in the refrigerator (4°C) for 3 hours and filter off any precipitate.

Following reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 1 week at 4°C.
Appearance :
Crystalline powder
Physical State :
Solid
Solubility :
Soluble in ethanol. Insoluble in water, chloroform, and ether.
Storage :
Store at room temperature
Melting Point :
230-240° C (lit.)(dec.)
Density :
~1.6 g/cm3 (Predicted)
Refractive Index :
n20D 1.66 (Predicted)
Optical Activity :
α20/D -54°, c = 2.8 in methanol; α20/D -53°±4°, c = 1 in ethanol; α20/D -48°±1°, c = 10 in AcOH; α20/D -48°±1°, c = 70 in AcOH
IC50 :
Flt-1: IC50 = 3.86 µM (human); MC5-R: IC50 = 3.88 µM (human); HT-29: IC50 = 5.6 µM (human); HCT-116: IC50 = 8.7 µM (human)
Ki Data :
Flt-1: Ki= 1.00 µM (human); MC5-R: Ki= 3.64 µM (human)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
IH2050050
Transport :
UN 3462, Class 6.1, Packing group III
PubChem CID :
6474107
Merck Index :
14: 3161
MDL Number :
MFCD00077729
EC Number :
234-255-6
Beilstein Registry :
78654
SMILES :
C[C@@H]1CC[C@@]2([C@H]([C@H]3[C@@H](O2)[C@H]([C@@H]4[C@@]3(CC[C@H]5[C@H]4CC[C@@H]6[C@@]5(C[C@H]([C@@H](C6)O[C@H]7[C@@H]([C@H]([C@H]([C@H](O7)CO)O[C@H]8[C@@H]([C@H]([C@@H]([C@H](O8)CO)O)O[C@H]9[C@@H]([C@H]([C@@H](CO9)O)O)O)O[C@H]2[C@@H]([C@H]([C@H]([C@H](O2)CO)O)O[C@H]2[C@@H]([C@H]([C@@H]([C@H](O2)CO)O)O)O)O)O)O)O)C)C)O)C)OC1

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Digitonin  Product Citations

See how others have used Digitonin. Click on the entry to view the PubMed entry .

Citations 1 to 2 of 2 total

PMID: # 28928238  Vierra, NC. et al. 2017. Sci Signal. 10:

PMID: # 26879809  Freyberg, Z. et al. 2016. Nat Commun. 7: 10652.

Citations 1 to 2 of 2 total
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Rated 5 out of 5 by from Krstin et al Krstin et al. (PubMed ID 26349826) found that Digitonin significantly stimulated alkaloid activity against trypanosomes. -SCBT Publication Review
Date published: 2015-03-28
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