Diethyldithiocarbamic acid sodium salt trihydrate A Nitric oxide (NO) spin-trapping reagent

Diethyldithiocarbamic acid sodium salt trihydrate (CAS 20624-25-3)

Diethyldithiocarbamic acid sodium salt trihydrate | CAS 20624-25-3 is rated 5.0 out of 5 by 1.
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Synonym: Sodium diethyldithiocarbamate trihydrate
Application: A Nitric oxide (NO) spin-trapping reagent
CAS Number: 20624-25-3
Purity: ≥99% (Titration)
Molecular Weight: 225.31
Molecular Formula: C5H10NS2•Na•3H2O
* Refer to Certificate of Analysis for lot specific data (including water content).
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Diethyldithiocarbamic acid sodium salt trihydrateis a dithiol compound that forms an NO-reactive spin-trapping agent when complexed with Fe2+. The Fe2+-DETC complex is described to be an efficient selective NO trap for EPR experiments, and the nitrosyl-iron-dithiocarbamate NOFe(DETC)2 reacted compound is identifiable with a characteristic triplet EPR signature. Diethyldithiocarbamic acid sodium salt trihydrate is an inhibitor of SOD and NF κ B.


References

1. Mülsch, A., et al. 1992. Biochem. J. 288: 597-603. PMID: 1281408
2. Paschenko, S.V., et al. 1996. Biochem. Biophys. Res. Commun. 225: 577-584. PMID: 8753803
3. Wallis, G., et al. 1996. Shock. 6: 274-278. PMID: 8902945
4. Mikoyan, V.D., et al. 1997. Biochim. Biophys. Acta. 1336: 225-234. PMID: 9305794
5. Vanin, A.F. 1999. Meth. Enzymol. 301: 269-279. PMID: 9919576
6. Malyshev, I.Y., et al. 1999. Nitric Oxide. 3: 105-113. PMID: 10369180

Physical State :
Solid
Solubility :
Soluble in water (20 mg/ml), ethanol, methanol, and acetone. Insoluble in ether.
Storage :
Store at 4° C
Melting Point :
95-98.5° C
Boiling Point :
176.4° C at 760 mmHg (Predicted)
Density :
1.1 g/cm3
Refractive Index :
n20D ~1.56
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
EZ6550000
PubChem CID :
517546
Merck Index :
14: 3378
MDL Number :
MFCD00150617
EC Number :
205-710-6
Beilstein Registry :
3920507
SMILES :
CCN(CC)C(=S)[S-].O.O.O.[Na+]

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Certificate of Analysis

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Rated 5 out of 5 by from Various publications cite Diethyldithiocarbamic Various publications cite Diethyldithiocarbamic acid sodium salt trihydrate forms an NO-reactive spin-trapping agent when complexed with Fe2+. The Fe2+-DETC complex is described to be an efficient selective NO trap for EPR experiments, and the nitrosyl-iron-dithiocarbamate NOFe(DETC)2 reacted compound is identifiable with a characteristic triplet EPR signature. -SCBT Publication Review
Date published: 2015-01-25
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